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Biological Reactive Intermediates IV

Molecular and Cellular Effects and Their Impact on Human Health

  • Book
  • © 1991

Overview

Editors:
  1. Charlotte M. Witmer

    1. Rutgers University, Piscataway, USA

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  2. Robert R. Snyder

    1. Rutgers University, Piscataway, USA

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  3. David J. Jollow

    1. Medical University of South Carolina, Charleston, USA

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  4. George F. Kalf

    1. Thomas Jefferson University, Philadelphia, USA

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  5. James J. Kocsis

    1. Thomas Jefferson University, Philadelphia, USA

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  6. I. Glenn Sipes

    1. University of Arizona, Tucson, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 283)

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Table of contents (122 chapters)

  1. Sessions I – VI

    1. Molecular Targets of Chemical Mutagens

      • Bradley D. Preston, Rupa Doshi
      Pages 193-209

    2. Mutagenic Consequences of the Alteration of DNA by Chemicals and Radiation

      • Bernard Strauss, Edith Turkington, Jhy Wang, Daphna Sagher
      Pages 211-223

    3. Gene Specific Damage and Repair after Treatment of Cells with UV and Chemotherapeutical Agents

      • Vilhelm A. Bohr
      Pages 225-233

    4. Proto-Oncogene Activation in Rodent and Human Tumors

      • Marshall W. Anderson, Ming You, Steven H. Reynolds
      Pages 235-243

  2. Short Communications

    1. Toxicity of 3-Methyleneoxindole, a Proposed Reactive Intermediate in the Metabolism of 3-Methylindole

      • Martin L. Appleton, Douglas N. Larson, Gary L. Skiles, William K. Nichols, Garold S. Yost
      Pages 245-248

    2. The Role of Cytochrome P450IIE1 in Bioactivation of Acetaminophen in Diabetic and Acetone-Treated Mice

      • E. H. Jeffery, K. Arndt, W. M. Haschek
      Pages 249-251

    3. Arylamine-Induced Hemolytic Anemia: Electron Spin Resonance Spectrometry Studies

      • Timothy P. Bradshaw, D. C. McMillan, R. K. Crouch, D. J. Jollow
      Pages 253-255

    4. Selective Alterations in the Profiles of Newly Synthesized Proteins by Acetaminophen (APAP) and its Dimethylated Analogues: Relationship to Oxidative Stress

      • Mary K. Bruno, Steven D. Cohen, Edward A. Khairallah
      Pages 257-260

    5. Benzene Metabolism by Two Purified, Reconstituted Rat Hepatic Mixed Function Oxidase Systems

      • Thomas A. Chepiga, Chung S. Yang, Robert Snyder
      Pages 261-265

    6. Stereochemical Induction of Cytochrome P450IVA1 (P452) and Peroxisome Proliferation in Male Rat

      • Edwin C. Chinje, G. Gordon Gibson
      Pages 267-270

    7. Cyanide Liberation and Oxidative Stress by Organothiocyanates, Organonitriles and Nitroprusside in Isolated Hepatocytes

      • Sahar Elguindi, Peter J. O’Brien
      Pages 271-274

    8. Mixed Function Oxidase Enzyme Responses to in Vivo and in Vitro Chromate Treatment

      • Ellen C. Faria, Charlotte M. Witmer
      Pages 275-280

    9. Fatty Acid β-Oxidation-Dependent Bioactivation of 5,6-Dichloro-4-Thia-5-Hexenoate and Analogs in Isolated Rat Hepatocytes

      • M. E. Fitzsimmons, M. W. Anders
      Pages 281-284

    10. Role of the Acetone Inducible P-450IIE1 in the Deethylation of Diethylnitrosamine in Hamster

      • P. G. Gervasi, P. Puccini, V. Longo, A. Lippi
      Pages 285-287

    11. Stereochemistry of the Microsomal Glutathione S-Transferase-Catalyzed Addition of Glutathione to Chlorotrifluoroethene in Isolated Rat Hepatocytes

      • Sally J. Hargus, Michael E. Fitzsimmons, M. W. Anders
      Pages 289-293

    12. The Pathophysiological Significance of Reactive Oxygen Formation in Rat Liver

      • Hartmut Jaeschke, Arthur E. Benzick, Charles V. Smith, Jerry R. Mitchell
      Pages 295-298

    13. Oxidative Stress during Hypoxia in Isolated-Perfused Rat Heart

      • James P. Kehrer, Youngja Park
      Pages 299-304

    14. Alteration of Growth Rate and Fibronectin by Imbalances in Superoxide Dismutase and Glutathione Peroxidase Activity

      • Michael J. Kelner, Richard Bagnell
      Pages 305-309

    15. The Antidotal Activity of the Thiol Drug Diethyldithiocarbamate Against N-Acetyl-p-Benzoquinone Imine in Isolated Hepatocytes

      • Veronique V. Lauriault, Peter J. O’Brien
      Pages 311-314

    16. Two Classes of Azo Dye Reductase Activity Associated with Rat Liver Microsomal Cytochrome P-450

      • Walter G. Levine, Shmuel Zbaida
      Pages 315-321
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Keywords

About this book

The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of research led to subsequent symposia at the University of Surrey, in England in 1980 (Snyder et al. , 1982), and the University of Maryland in the U. S. A. in 1985 (Kocsis et al. , 1986). The Fourth International Symposium on Biological Reactive Intermediates was hosted by the Center for Toxicology at the University of Arizona and convened in Tucson, Arizona, January 14-17, 1990. Over 300 people attended. There were 60 platform presentations by invited speakers, and 96 volunteer communications in the form of posters were offered. These meetings have grown from a small group of scientists working in closely related areas to a major international series of symposia which convene every five years to review, and place in context, the latest advances in our understanding of the formation, fate and consequences of biological reactive intermediates. The Organizing Committee: Allan H. Conney, Robert Snyder (Co-chairman), and Charlotte M. Witmer (Rutgers University, Piscataway, NJ), David J. Jollow Co­ chairman) (Medical University, South Carolina, Charleston, SC), 1. Glenn Sipes (Co­ chairman) (University of Arizona, Tucson, AZ), James J. Kocsis and George F.

Editors and Affiliations

  • Rutgers University, Piscataway, USA

    Charlotte M. Witmer, Robert R. Snyder

  • Medical University of South Carolina, Charleston, USA

    David J. Jollow

  • Thomas Jefferson University, Philadelphia, USA

    George F. Kalf, James J. Kocsis

  • University of Arizona, Tucson, USA

    I. Glenn Sipes

Bibliographic Information

  • Book Title: Biological Reactive Intermediates IV

  • Book Subtitle: Molecular and Cellular Effects and Their Impact on Human Health

  • Editors: Charlotte M. Witmer, Robert R. Snyder, David J. Jollow, George F. Kalf, James J. Kocsis, I. Glenn Sipes

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5877-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1991

  • Softcover ISBN: 978-1-4684-5879-4Published: 08 July 2012

  • eBook ISBN: 978-1-4684-5877-0Published: 09 March 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: 912

  • Number of Illustrations: 87 b/w illustrations

  • Topics: Oncology, Pharmacology/Toxicology, Biochemistry, general

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