Table of contents

  1. Front Matter
    Pages i-xxii
  2. Steven Specter, Herman Friedman, Mauro Bendinelli
    Pages 1-18
  3. Giuseppe Barbanti-Brodano
    Pages 41-57
  4. Warren A. Andiman, Marie F. Robert
    Pages 59-72
  5. Laure Aurelian
    Pages 73-100
  6. Joseph L. Waner
    Pages 101-124
  7. David T. Purtilo, Helen L. Grierson
    Pages 125-140
  8. Lorne A. Babiuk, M. J. P. Lawman, P. Griebel
    Pages 141-171
  9. David S. Strayer
    Pages 173-192
  10. Carlo Garzelli, Takashi Onodera
    Pages 193-200
  11. Jagdev M. Sharma, J. M. Dupuy, L. Lamontagne
    Pages 201-216
  12. Carlo Garzelli, Fulvio Basolo, Donatella Matteucci, Bellur S. Prabhakar, Antonio Toniolo
    Pages 217-234
  13. Kathryn E. Wright, William E. Rawls
    Pages 235-251
  14. Umesh C. Chaturvedi
    Pages 253-283
  15. Man-Sun Sy, Robert Finberg
    Pages 285-301
  16. Norbert J. Roberts Jr., Frank Domurat
    Pages 303-326
  17. Raija Vainionpää, Timo Hyypiä
    Pages 327-343
  18. Paolo Casali, Minoru Nakamura, Michael B. McChesney
    Pages 345-373
  19. Robert W. Storms, Henry R. Bose Jr.
    Pages 375-393
  20. Steven Specter, Mauro Bendinelli, Herman Friedman
    Pages 395-419
  21. Mayra Lopez-Cepero, Steven Specter, John Hadden
    Pages 421-436
  22. Mauro Bendinelli, Steven Specter, Herman Friedman
    Pages 441-457
  23. Back Matter
    Pages 459-477

About this book


It is now widely acknowledged that at the beginning of this century Claude von Pirquet first pointed out that a viral disease, i. e. , measles, resulted in an anergy or depression of preexisting immune response, namely, delayed continuous hypersensitivity to PPD derived from Mycobacterium tuberculosis. Thereafter ob­ servations that viral infections may result in immunosuppression have been recorded by many clinicians and infectious disease investigators for six or seven decades. Nevertheless, despite sporadic reports that infectious diseases caused by viruses may result in either transient or prolonged immunodepression, investigation of this phenomenon languished until the mid-1960s, when it was pointed out that a number of experimental retroviral infections of mice with tumor viruses may result in marked immunosuppression. However, it was not until the recognition of the new epidemic of acquired immunodeficiency syn­ drome (AIDS) caused by the human immunodeficiency virus and related vi­ ruses that acquired immunodeficiencies associated with virus infection became general knowledge among biomedical investigators as well as the lay public. A number of reviews published during the past decade or so pointed out that numerous viruses may affect humoral and cellular immune responses. Furthermore, expanding knowledge about the nature and mechanisms of both humoral and cellular immunity and pathogenesis of viral infections has pro­ vided clinical and experimental models for investigating in depth how and why viruses of man and animals profoundly affect immune responses.


AIDS Pathogene infection infections infectious infectious disease infectious diseases viral infection virus

Editors and affiliations

  • Steven Specter
    • 1
  • Mauro Bendinelli
    • 2
  • Herman Friedman
    • 1
  1. 1.Department of Medical Microbiology and Immunology, College of MedicineUniversity of South FloridaTampaUSA
  2. 2.Department of BiomedicineUniversity of PisaPisaItaly

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1989
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5585-4
  • Online ISBN 978-1-4684-5583-0
  • Series Print ISSN 1075-1289
  • Buy this book on publisher's site