Principles of Endocrine Pharmacology

  • John A. Thomas
  • Edward J. Keenan

Table of contents

  1. Front Matter
    Pages i-xvi
  2. John A. Thomas, Edward J. Keenan
    Pages 1-14
  3. John A. Thomas, Edward J. Keenan
    Pages 15-42
  4. John A. Thomas, Edward J. Keenan
    Pages 43-68
  5. John A. Thomas, Edward J. Keenan
    Pages 69-91
  6. John A. Thomas, Edward J. Keenan
    Pages 93-109
  7. John A. Thomas, Edward J. Keenan
    Pages 111-133
  8. John A. Thomas, Edward J. Keenan
    Pages 135-165
  9. John A. Thomas, Edward J. Keenan
    Pages 167-196
  10. John A. Thomas, Edward J. Keenan
    Pages 197-227
  11. John A. Thomas, Edward J. Keenan
    Pages 229-256
  12. John A. Thomas, Edward J. Keenan
    Pages 257-290
  13. Back Matter
    Pages 291-294

About this book

Introduction

The authors have provided an overview of the relationships between hormones that are physiologic constituents of the body as well as their pharmacologic use in replacement therapies and related endocrine dys­ function. Principles of Endocrine Pharmacology concerns itself with the ther­ apeutic use of hormones, and hormone like substances, or drugs that can act either by suppressing or enhancing the metabolism of certain glands of internal secretion. Other drugs used for nonendocrine ther­ apies can likewise affect the endocrine system. Endocrine pharmacology emerged in the early 1900s with the use of crude pituitary extracts. By the mid-1900s several investigators had isolated and begun to synthesize hormones or hormonelike substances. Recognizing the limited supply of hormones that could be obtained both from animal sources and human autopsy material, the search for so­ called hormone substitutes also began early in the 1900s. Recently, re­ combinant DNA technologies have been used to provide alternative therapeutic sources of human insulin and human growth hormone. Aside from insulin, perhaps no other use of hormonally-active sub­ stance is better exemplified by those drugs which affect fertility. The synthesis of an orally-effective steroid represented one of the first major breakthroughs in the chemical suppression of ovulation. Since the orally­ active 19-norsteroids were introduced in the 1950s, several oral contra­ ceptive steroid preparations have been marketed. Indeed, the advent of oral contraceptives for birth control has led to a renewed interest in endocrine pharmacology.

Keywords

Insulin metabolism pharmacology steroids

Authors and affiliations

  • John A. Thomas
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Edward J. Keenan
    • 7
    • 8
    • 9
    • 10
  1. 1.Corporate ResearchTravenol Laboratories, Inc.Round LakeUSA
  2. 2.Department of PharmacologyNorthwestern University School of MedicineChicagoUSA
  3. 3.Department of UrologyNorthwestern University School of MedicineChicagoUSA
  4. 4.Department of Pharmacology and ToxicologyWest Virginia School of MedicineMorgantownUSA
  5. 5.Department of PharmacologyUniversity of Illinois School of MedicineChicagoUSA
  6. 6.Department of PharmacologyRush-Presbyterian School of MedicineChicagoUSA
  7. 7.Hormone Receptor Laboratory, School of MedicineThe Oregon Health Sciences UniversityPortlandUSA
  8. 8.Department of Surgery, School of MedicineThe Oregon Health Sciences UniversityPortlandUSA
  9. 9.Department of Pharmacology, School of MedicineThe Oregon Health Sciences UniversityPortlandUSA
  10. 10.Department of Medicine (Medical Oncology), School of MedicineThe Oregon Health Sciences UniversityPortlandUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-5036-1
  • Copyright Information Springer-Verlag US 1986
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-306-42143-3
  • Online ISBN 978-1-4684-5036-1
  • About this book