Gene Expression in Muscle

  • Richard C. Strohman
  • Stewart Wolf

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 182)

Table of contents

  1. Front Matter
    Pages i-x
  2. Background

  3. Phenotypic Expression & Molecular Markers for Muscle Diseases

    1. Front Matter
      Pages 23-23
    2. Armand F. Miranda, Tiziana Mongini, Salvatore DiMauro
      Pages 25-42
    3. Joseph F. Y. Hoh, R. B. Fitzsimons
      Pages 43-62
    4. Helen M. Blau, Cecilia Webster, Grace K. Pavlath, Choy-Pik Chiu
      Pages 85-110
  4. Regulatory Influences on Muscle Growth

    1. Front Matter
      Pages 111-111
    2. S. Hauschka, R. Lim, C. Clegg, J. Chamberlain, C. Bulinski, T. Linkhart
      Pages 113-122
    3. T. H. Oh, G. J. Markelonis, T. Dion Guidera, S. L. Hobbs, L. P. Park
      Pages 129-135
    4. Ryoichi Matsuda, Richard C. Strohman
      Pages 137-140
    5. Neal A. Rubinstein, Gary E. Lyons, Brigitte Gambke, Alan Kelly
      Pages 141-153
    6. A. Kelly, G. Lyons, B. Gambki, N. Rubinstein
      Pages 155-168
    7. Dirk Pette, Annegard Heilig, Gary Klug, Heinz Reichmann, Udo Seedorf, Walter Wiehrer
      Pages 169-177
    8. H. Holtzer, S. Forry-Schaudies, P. Antin, G. Dubyak, V. Nachmias
      Pages 179-192
    9. Robert G. Whalen, Lawrence B. Bugaisky, Gillian S. Butler-Browne, Marion S. Ecob, Christian Pinset
      Pages 193-199
  5. Regulating Expression of Protein Isoforms

    1. Front Matter
      Pages 201-201
    2. Donald A. Fischman, David Bader, Takashi Obinata
      Pages 203-214
    3. Henry F. Epstein
      Pages 215-222
    4. James I. Garrels, Shigeko Yamashiro-Matsumura, Jim J.-C. Lin, Fumio Matsumura
      Pages 223-230
    5. Helen M. Blau, Choy-Pik Chiu, Grace K. Pavlath, Cecelia Webster
      Pages 231-247
    6. Robert G. Whalen, Gillian S. Butler-Browne, Lawrence B. Bugaisky, John B. Harris, Danielle Herliocoviez
      Pages 249-257
    7. Richard C. Strohman, Ryoichi Matsuda
      Pages 259-263
  6. Recombinant DNA Approaches in the Investigation of Muscle Gene Expression

    1. Front Matter
      Pages 281-281
    2. Henry F. Epstein
      Pages 283-285
    3. Louis Kunkel, Gail Burns, Jeff Aldrige, Samuel Latt
      Pages 287-294
    4. David Yaffe, Uri Nudel, Henryk Czosnek, Danielle Melloul, Batya Aloni
      Pages 295-307
    5. M. Buckingham, S. Alonso, G. Bugaisky, P. Barton, A. Cohen, P. Daubas et al.
      Pages 333-344
  7. Summary and Synthesis

    1. Front Matter
      Pages 357-357
    2. R. Rodney Howell
      Pages 359-361
  8. Coda

    1. Richard C. Strohman, Stewart Wolf
      Pages 363-366
  9. Back Matter
    Pages 367-434

About this book


This volume contains the edited transcript of an interdisci­ plinary colloquium held at Totts Gap Medical Research Laboratories, Bangor, Pennsylvania on October 12-14, 1983 under the sponsorship of the Muscular Dystrophy Association. The aim was to illuminate the pathogenic mechanism of Duchenne Muscular Dystrophy through a synthesis of available data on gene expression in muscle. In the informal give and take ot the collo­ quium, the participants found themselves engaged in mutual education and enlightenment as they attempted to put together what is known and to highlight what is not known about the subject. Significant research into muscle as a tissue and muscle disease began only about 50 years ago although the description of muscular dystrophy by Guillaume Benjamin Amand Duchenne de Boulogne had been published in 1862. By 1943 it was clear that Duchenne muscular dystrophy was an X-linked genetic disorder. Up to the present, however, the offending gene has not been identified although its location on the short arm of the X chromosome has been approximately determined. The gene product associated with the initial disturbance in skeletal muscle has also remained elusive up to now. Moreover, investigations into the mechanisms of the muscle degeneration have been hampered by ignorance of the fundamental phenotypic expression of the genetic disorder.


chromosome gene expression genes

Editors and affiliations

  • Richard C. Strohman
    • 1
  • Stewart Wolf
    • 2
    • 3
  1. 1.University of CaliforniaBerkeleyUSA
  2. 2.Totts Gap Medical Research LaboratoriesBangorUSA
  3. 3.Temple UniversityPhiladelphiaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1985
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-4909-9
  • Online ISBN 978-1-4684-4907-5
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site