Molecular Basis of Insulin Action

  • Michael P. Czech

Table of contents

  1. Front Matter
    Pages i-xv
  2. Signal Initiation by the Insulin Receptor

    1. Front Matter
      Pages 1-1
    2. Jeffrey E. Pessin, Cristina Mottola, Kin-Tak Yu, Michael P. Czech
      Pages 3-29
    3. C. Ronald Kahn, Morris F. White, Florin Grigorescu, Sumiko Takayama, Hans U. Häring, Marco Crettaz
      Pages 67-93
    4. Paul F. Pilch, Michael A. Shia, Joshua B. Rubin
      Pages 95-100
  3. Intracellular Signaling Mechanisms of Insulin Action

    1. Front Matter
      Pages 101-101
    2. Jay M. McDonald, Harrihar A. Pershadsingh
      Pages 103-117
    3. Richard D. Moore
      Pages 145-170
    4. K. Cheng, M. Thompson, C. Schwartz, C. Malchoff, S. Tamura, J. Craig et al.
      Pages 171-182
    5. Leonard Jarett, S. Lance Macaulay, Janice C. Parker, Kathleen L. Kelly, Frederick L. Kiechle
      Pages 183-198
    6. Jonathan R. Seals
      Pages 199-210
  4. Mechanisms of Target Enzyme Modulation by Insulin Action

    1. Front Matter
      Pages 211-211
    2. Philip Cohen, Peter J. Parker, James R. Woodgett
      Pages 213-233
    3. Thomas R. Soderling, Virender S. Sheorain
      Pages 235-245
    4. Joseph Avruch, Raphael A. Nemenoff, Mark Pierce, Yan C. Kwok, Perry J. Blackshear
      Pages 263-296
    5. Roger W. Brownsey, Richard M. Denton
      Pages 297-314
  5. Control of Gene Expression by Insulin

    1. Front Matter
      Pages 327-327
    2. I. D. Goldfine, F. Purrello, R. Vigneri, G. A. Clawson
      Pages 329-345
    3. David S. Loose, Anthony Wynshaw-Boris, Herman M. Meisner, Yaacov Hod, Richard W. Hanson
      Pages 347-368
    4. Michele A. Cimbala, David Lau, Joseph F. Daigneault
      Pages 385-395
  6. Regulation of Membrane Components by Insulin

  7. Back Matter
    Pages 465-473

About this book


One day, in a moment of weakness, I fell prey to the temptation to organize and edit this volume on the mechanism of insulin action. The major reason for attempting to resist, of course, is the amazing speed at which advances are being made in this field. The usefulness of books such as this is often quickly compromised by new findings obtained during and just after publication. Happily for the contributors to this volume and myself, this unfortunate fate does not appear to be in store for us. New and important findings will undoubtedly continue to flow in this field during the next few years, but I believe this will increase rather than decrease the usefulness of this volume. As a matter of fact, as we go to press, I am delighted both that I was tempted and that I failed to resist. There are two basic reasons for my enthusiasm about this book, and they both relate to this issue of timeliness. First, each of the contributors has had an opportunity to update the scientific content of the various chapters only a few months before actual publication of this volume. The material presented in this volume is, at publication, contemporary with the current original literature. This volume thus provides an ex­ cellent framework for assessing new discoveries in this field for some time to come.


ATP Calcium Glycogen cell cell membrane enzyme enzymes gene expression genes metabolism phosphorylation protein receptor regulation research

Editors and affiliations

  • Michael P. Czech
    • 1
  1. 1.Department of BiochemistryUniversity of Massachusetts Medical SchoolWorcesterUSA

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