The Interleukins

  • Steven Gillis
  • F. P. Inman

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Verner Paetkau, R. Chris Bleackley, Denis Riendeau, Delsworth G. Harnish, Eugene W. Holowachuk
    Pages 35-61
  3. John W. Schrader, Ian Clark-Lewis, Richard M. Crapper, Grace H. W. Wong, Sabariah Schrader
    Pages 121-146
  4. Maureen Howard
    Pages 181-193
  5. Peter E. Lipsky
    Pages 195-217
  6. Susan L. Swain, Richard W. Dutton
    Pages 219-229
  7. Martin A. Cheever, Philip D. Greenberg
    Pages 263-282
  8. Back Matter
    Pages 283-291

About this book

Introduction

Investigations of the activation, proliferation, and, in some cases, differentia­ tion of mononuclear cells involved in the immune response are proceeding rapidly. These studies have resulted in the discovery of several factors that promote these cellular events, some of which have been characterized biochemically to various extents. Because of the considerable interest in understanding these cellular changes at the molecular level, we chose to produce the first thematic volume for Contemporary Topics in Molecular Immunology; the theme deals with certain regulatory factors that promote proliferation and differentiation. We have com­ piled contributions from numerous scientists well known for their work with several regulatory factors. In the following paragraphs, the reader will find an overview of the contents of this volume. Greene and Robb review data they have generated over the past 2-3 years with respect to characterization of hormone-specific Interleukin-2 (IL-2) recep­ tors on the surface of activated T cells. Their chapter traces the development of a quantitative assay for assessment of IL-2 receptors based on the preparation and use of radiolabeled IL-2 prepared biosynthetically with the aid of IL-2-pro­ ducer leukemic cells. The authors then describe an alternate approach, the prep­ aration of a monoclonal antibody previously determined to be directed against a T -cell-activation antigen. This so-called anti-Tac antibody was later found to recognize a determinant on or near the IL-2 receptor.

Keywords

antibody antigen biochemistry biology cell chemistry growth growth factor immune response immunology molecular biology

Editors and affiliations

  • Steven Gillis
    • 1
  • F. P. Inman
    • 2
  1. 1.Immunex CorporationSeattleUSA
  2. 2.Department of Biochemistry, Quillen-Dishner College of MedicineEast Tennessee State UniversityJohnson CityUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-4838-2
  • Copyright Information Springer-Verlag US 1985
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-4840-5
  • Online ISBN 978-1-4684-4838-2
  • About this book