Molecular Aspects of Early Development

  • George M. Malacinski
  • William H. Klein

Table of contents

  1. Front Matter
    Pages i-viii
  2. William R. Jeffery, Craig R. Tomlinson, Richard D. Brodeur, Stephen Meier
    Pages 1-38
  3. Bruce P. Brandhorst, Frank Tufaro, Pierre-Andre Bedard
    Pages 39-60
  4. Joan V. Ruderman, Eric T. Rosenthal, Terese Tansey
    Pages 61-86
  5. Robert C. Angerer, Kathleen J. Hughes, Donna V. DeLeon, David A. Lynn, Lynne M. Angerer
    Pages 87-107
  6. Richard M. Showman, Dan E. Wells, John A. Anstrom, Deborah A. Hursh, David S. Leaf, Rudolf A. Raff
    Pages 109-130
  7. William H. Klein, Lisa M. Spain, Angela L. Tyner, John Anstrom, Richard M. Showman, Clifford D. Carpenter et al.
    Pages 131-140
  8. Judith A. Lengyel, Steven R. Thomas, Paul David Boyer, Fidel Salas, Teresa R. Strecker, Inyong Lee et al.
    Pages 219-251
  9. Linda E. Hyman, Hildur V. Colot, Michael Rosbash
    Pages 253-266
  10. Debbie Crise Meuler, George M. Malacinski
    Pages 267-288
  11. Back Matter
    Pages 309-324

About this book


The early embryo has emerged as the focal point for analysis of the regulation of gene expression for several reasons. First, the fact that embryogenesis is under genetic control has been appreciated from the earliest days of classical embryology. When experimental techniques became available it was therefore logical that they should be applied to the embryo. With each new advance in methodology, interest in embryonic gene expression studies has increased. Second, many embryos offer unique opportunities for the investigation of specific aspects of the regulation of gene expression. Several phenomena--eg. , control of translation--can be very conveniently studied in a variety of marine invertebrate embryos. Those embryos contain large stores of maternally inherited mRNA which are translated in a highly ordered fashion during specific stages of post fertilization development. Marine invertebrate eggs can be conveniently artifically inseminated and labeled with radioactive precursors. Their analysis is leading to important insights into the mechanisms which regulate gene expression at post-transcriptional levels. Third, recent advances in both transmission and recombinant DNA genetics, especially in organisms such as Drosophila, are providing special opportunities for the analysis of regulatory mechanisms which operate at the level of the genome. Specific genes have been identified, isolated, and--in some instances--sequenced. The opportunity is now available to study the regulation of the expression of single genes in a vertical fashion--from the primary sequence of the gene to the tissues and organs which are the products of morphogenesis.


DNA Drosophila Invertebrate Termination Vertebrate Xenopus laevis development embryo embryology gene expression genes genetics morphogenesis transcription translation

Editors and affiliations

  • George M. Malacinski
    • 1
  • William H. Klein
    • 1
  1. 1.Indiana UniversityBloomingtonUSA

Bibliographic information