• N. Fabris
  • E. Garaci
  • John Hadden
  • N. A. Mitchison

Table of contents

  1. Front Matter
    Pages i-ix
  2. T. Tada, G. Suzuki, R. Abe, Y. Kumagai, K. Hiramatsu, S. Miyatani
    Pages 1-11
  3. Max D. Cooper, Toru Abo, Willem A. Kamps, Patricia L. Haber, Charles M. Balch
    Pages 13-24
  4. M. Ricci, S. Romagnani, Grazia M. Giudizi, F. Aimerigogna, Roberta Biagiotti, G. F. Del Prete et al.
    Pages 25-33
  5. N. A. Mitchison
    Pages 35-43
  6. G. Doria, C. Mancini, Giovanna Agarossi, Daniela Fioravanti, S. Vietri, L. Adorini
    Pages 49-56
  7. G. C. Andrighetto, B. Benato, G. Tridente
    Pages 69-92
  8. Marc Feldmann, Alain Fischer, Roger James, Eric Culbert, Mike Cecka, Ian Todd et al.
    Pages 93-122
  9. Luciano Adorini, Carlo Pini, Camillo Mancini, Gino Doria, Paola Ricciardi-Castagnoli
    Pages 123-132
  10. Nicholas R. Hall, Allan L. Goldstein
    Pages 141-163
  11. E. Garaci, F. Bistoni, C. Favalli, P. Marconi, V. Del Gobbo, C. Rinaldi et al.
    Pages 165-176
  12. D. C. Dumonde, Anne S. Hamblin, Eva Kasp-Grochowska, Melanie S. Pulley, R. A. Wolstencroft
    Pages 177-199
  13. Bernard M. Jaffe, M. Gabriella Santoro, Peter Le Port, Cartesio Favalli, David Hofer, Enrico Garaci
    Pages 271-281
  14. Robert Ader
    Pages 283-313
  15. Hugo O. Besedovsky, Adriana del Rey, Ernst Sorkin
    Pages 315-339
  16. N. Fabris, E. Mocchegiani, M. Muzzioli, R. Imberti
    Pages 341-362
  17. David F. Horrobin
    Pages 373-383
  18. Roy L. Walford, Faramarz Naeim, Kathleen Y. Hall, C. F. Tam, Richard A. Gatti, Michael A. Medici
    Pages 399-417
  19. Anna Maria Iorio, Franca Campanile, Mariela Neri, Abraham Goldin, Enzo Bonmassar
    Pages 419-452
  20. S. Katzav, P. De Baetselier, B. Tartakovsky, E. Gorelik, S. Segal, M. Feldman
    Pages 453-463
  21. Back Matter
    Pages 465-477

About this book


Immunoregulation is one of the areas which has witnessed the most explosive advances of immunology during the past decade. It is in this area that the current view of the immune system has arisen and developed. There is indeed little doubt that immune reactions are primarily determined by messages which are genera ted within the immune system and passed among different types of immunologie cells. This cell communication not only determines the type, intensity and duration of the response after perturbation of the immune system by exogenous antigens, but it is also essential for preventing autoimmune reactions and their clinical conse­ quences. In order to assure aperfect balance within the enormous com­ plexity of the immune system, it is not surprising that multiple self-regulatory mechanisms are organized at different levels, such as antibody feedback, idiotypic-anti-idiotypic responses, suppres­ sor and helper T cells, lymphokine signals and genetic require­ ments. A nu mb er of observations in recent years have, however, demonstrated that consistent contributions to the immunological homeostasis are given also by signals generated outside of the immune system, namely,in the central and autonomous nervous system as weIl as in the endocrine apparatus. Furthermore, the interactions between the immune system and the other body homestatic mechanisms seem to be bidirectional: if immunological cells may be targets of neuroendocrinological factors, immunological products seem in turn to contribute to the neuro­ endocrine homeostasis.


T cell Thymus antibody antigen autoimmune disease blood diseases immune response immune system immunity immunodeficiency immunology lymphocytes pathogenesis proteins

Editors and affiliations

  • N. Fabris
    • 1
  • E. Garaci
    • 2
  • John Hadden
    • 3
  • N. A. Mitchison
    • 4
  1. 1.Italian National Institute on AgingAnconaItaly
  2. 2.Institute of MicrobiologyRomeItaly
  3. 3.University of South Florida Medical CollegeTampaUSA
  4. 4.University CollegeLondonEngland

Bibliographic information