Drug Metabolite Isolation and Determination

1. NOTES and COMMENTS relating to Investigation of metabolites, especially Phase I

   1. Front Matter

      Pages 135-135

      PDF

   2. A Note on Metabolic Fate of the Immunoadjuvant Peptidoglycan Monomer

      • Jelka Tomašić

      Pages 137-139

   3. A note on HPLC as a Means of Following anin vitro Synthesis of 7-Hydroxymethotrexate

      • Yahya Y. Z. Farid, Ian D. Watson, Nigel G. L. Harding, Michael J. Stewart

      Pages 141-142

2. Investigation of Conjugates

   1. Front Matter

      Pages 147-147

      PDF

   2. Isolation of Conjugates and Identification of the Attached Groups

      • Jelka Tomašić

      Pages 149-160

   3. Isolation and Characterization of Amino Acid and Sugar Conjugates of Xenobiotic Carboxylic Acids

      • John Caldwell, Andrew J. Hutt, Mary Varwell Marsh, Keith A. Sinclair

      Pages 161-179

   4. Chromatography, Hydrolysis and Rearrangement of the Glucuronide Conjugate of Isoxepac, as Affecting its Assay in Urine

      • I. D. Wilson, A. Bhatti, H. P. A. Illing, T. A. Bryce, J. Chamberlain

      Pages 181-187

3. NOTES and COMMENTS relating to Investigation of conjugates

   1. Front Matter

      Pages 189-189

      PDF

   2. A Note on Isolation and Identification of a Drug Conjugate

      • M. P. Harrison

      Pages 191-196

4. Determination of Particular Drugs and Metabolites

   1. Front Matter

      Pages 199-199

      PDF

   2. HPLC Analysis of the Major Urinary Metabolite of Flurazepam

      • J. A. F. de Silva, M. A. Brooks, M. R. Hackman, R. E. Weinfeld

      Pages 201-206

   3. Quantification of Metabolites of Aminopyrine and Antipyrine in Plasma and Urine

      • J. B. Houston, J. C. Rhodes

      Pages 207-214

   4. Immunoassay of Bromocriptine and Specificity of Antibody: Criteria for Choice of Antiserum and Marker Compound

      • J. Rosenthaler, H. Munzer, R. Voges

      Pages 215-223

   5. Determination of 3-Phenoxy-N-Methylmorphinan and Metabolites in Plasma

      • J. A. F. de Silva, J. Pao, M. A. Brooks

      Pages 225-230

   6. Assays where High Sensitivity was Achieved, Especially by HPTLC with Automatic Spotting and Colour Reactions

      • W. Ritter

      Pages 231-238

5. NOTES and COMMENTS relating to Determination of particular drugs and metabolites

   1. Front Matter

      Pages 239-239

      PDF

   2. A Note on Selective Column-Extraction of Psycho-Active Drugs and Metabolites

      • R. G. Muusze

      Pages 241-242

   3. A Note on Determination of Atracurium and Its Metabolites

      • E. A. M. Neill

      Pages 243-246

   4. A Note on Discrimination Between Carbon Monoxide as a Metabolite of Carbon Tetrachloride and as a Degradation Product of the Biological Material

      • L. J. King

      Pages 247-248

   5. A Note on HPLC Determination of Cefotaxime and Its Metabolites

      • J. Chamberlain, D. Dell, F. G. Coppin

      Pages 249-249

Scope of the book, and acknowledgements.- The articles are focused on 'real problems' in body-fluid analysis, typically with a final chromatographic separation of ~g or often ng amounts if the aim is quantitation. The pitfalls may not be realized by a typical chemist (cf. remarks in #A-3), but he may excel in metabolite iden­ tification - which this book covers to a fair extent. Where identity is known, and the metabolite could interfere in therapeutic drug monitoring or in diagnosis or itself have clinical relevance, useful guidance will come from articles that follow. Authors have gone to much trouble, and are not to be blamed by any reader who would have liked an introduction to chromatography or to metabolic pathways (cf. list of conjugation reactions at end of concluding article). Appre­ ciation is also expressed for permission to reproduce published mat­ erial; the acknowledged sources include 1. Chroma tog. (Elsevier; e. g. in #A-l) , Anal. Chem. (American Chemical Society; #A-2) and Wiley.

• carboxylic acid
• chromatography
• diagnosis
• phenol
• reactions
• society

• University of Surrey, UK

  Eric Reid, J. P. Leppard

Policies and ethics