Drug Metabolite Isolation and Determination

  • Eric Reid
  • J. P. Leppard

Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 12)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Techniques Applicable to Metabolite Investigation

  3. NOTES and COMMENTS relating to Techniques applicable to metabolite investigation

  4. Investigation of Metabolites, Especially Phase I

    1. Front Matter
      Pages 95-95
    2. Ian D. Watson, David R. Jarvie, Anne Chambers, Michael J. Stewart
      Pages 103-110
    3. J. D. Robinson, I. D. Wilson, C. D. Bevan, J. Chamberlain
      Pages 111-118

About this book

Introduction

Scope of the book, and acknowledgements.- The articles are focused on 'real problems' in body-fluid analysis, typically with a final chromatographic separation of ~g or often ng amounts if the aim is quantitation. The pitfalls may not be realized by a typical chemist (cf. remarks in #A-3), but he may excel in metabolite iden­ tification - which this book covers to a fair extent. Where identity is known, and the metabolite could interfere in therapeutic drug monitoring or in diagnosis or itself have clinical relevance, useful guidance will come from articles that follow. Authors have gone to much trouble, and are not to be blamed by any reader who would have liked an introduction to chromatography or to metabolic pathways (cf. list of conjugation reactions at end of concluding article). Appre­ ciation is also expressed for permission to reproduce published mat­ erial; the acknowledged sources include 1. Chroma tog. (Elsevier; e. g. in #A-l) , Anal. Chem. (American Chemical Society; #A-2) and Wiley.

Keywords

carboxylic acid chromatography diagnosis phenol reactions society

Editors and affiliations

  • Eric Reid
    • 1
  • J. P. Leppard
    • 1
  1. 1.University of SurreyUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-4484-1
  • Copyright Information Springer-Verlag US 1983
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-4486-5
  • Online ISBN 978-1-4684-4484-1
  • About this book