Organ and Species Specificity in Chemical Carcinogenesis

  • Robert Langenbach
  • Stephen Nesnow
  • Jerry M. Rice

Part of the Basic Life Sciences book series

Table of contents

  1. Front Matter
    Pages i-ix
  2. Jerry M. Rice, Charles H. Frith
    Pages 1-22
  3. Elizabeth K. Weisburger
    Pages 23-47
  4. Robert G. Croy, John M. Essigmann, Gerald N. Wogan
    Pages 49-62
  5. R. H. Adamson, S. M. Sieber
    Pages 129-156
  6. Stuart H. Yuspa, Henry Hennings, Ulrike Lichti, Molly Kulesz-Martin
    Pages 157-171
  7. John Reiners Jr., Kowetha Davidson, Kay Nelson, Mark Mamrack, Thomas Slaga
    Pages 173-188
  8. N. H. Colburn, T. D. Gindhart, B. Dalal, G. A. Hegamyer
    Pages 189-200
  9. Peter M. Blumberg, K. Barry Delclos, Susan Jaken
    Pages 201-229
  10. Samuel M. Cohen
    Pages 253-272
  11. James K. Selkirk, Michael C. MacLeod, Betty K. Mansfield, Patsy A. Nikbakht, Kris C. Dearstone
    Pages 283-294
  12. Coral A. Lamartiniere, George W. Lucier
    Pages 295-312
  13. James W. Allen, Yousuf Sharief, Robert Langenbach, Michael D. Waters
    Pages 451-472
  14. Herman Autrup, Roland C. Grafstrom, Curtis C. Harris
    Pages 473-495
  15. P. N. Magee
    Pages 497-508
  16. Paul Kleihues, Ruth M. Hodgson, Christof Veit, Fritz Schweinsberg, Manfred Wiessler
    Pages 509-529
  17. R. Montesano, H. Bresil, G. Planche-Martel, A. E. Pegg, G. Margison
    Pages 531-543
  18. C. Anita, H. Bigger, Anthony Dipple
    Pages 587-604
  19. James A. Swenberg, Mary A. Bedell, Kathryn C. Billings, James G. Lewis
    Pages 605-617
  20. Back Matter
    Pages 667-693

About this book


The Symposium on Organ and Species Specificity in Chemical Carcinogenesis was held March 1981 in Raleigh, North Carolina. Dr. James Miller concluded this Symposium with these remarks: "Without a doubt all of us would agree this has been a very successful symposium in illustrating a very wide range of chemical, stereochemical, biochemical, metabolic, molecular, and biological factors in chemical carcinogenesis. I think it is noteworthy that many of the discussions have dealt with pharmacodynamic, or toxicodynamic, factors that can influence the biological activities of the extremely wide range of structures that we choose to call chemical carcinogens. I sincerely hope that after this symposium everyone here will realize the very great need we have for further information on these agents in the species we profess to be working for, the human species. We badly need an adequate data base on human organs, human tissues, human cells, human subcellular preparations, and human body fluids. I don't think we can rely on extrapolations of data on chemical carcinogenesis from experimental animals to humans, no matter how sophisticated or plausible these extrapolations may seem, until we know far more about chemical carcinogenesis in humans. Now, I'd like to add a somewhat personal note. As many of you know, my wife and I have shared a joint career of some 40 years in this field, and I'd like to emphasize in these closing remarks the factor of youth.


Hamster Mamma Tumor base carcinogenesis cells joint mouse organ pharmacodynamics skin tissue

Editors and affiliations

  • Robert Langenbach
    • 1
  • Stephen Nesnow
    • 1
  • Jerry M. Rice
    • 2
  1. 1.U.S. Environmental Protection AgencyResearch Triangle ParkUSA
  2. 2.National Cancer InstituteBethesdaUSA

Bibliographic information