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Structural Molecular Biology

Methods and Applications

  • David B. Davies
  • Wolfram Saenger
  • Steven S. Danyluk

Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 45)

Table of contents

  1. Front Matter
    Pages i-x
  2. Keynote Address

  3. Methods

  4. Applications

    1. J. L. Finney, J. M. Goodfellow, P. L. Poole
      Pages 387-426
    2. Martin Karplus
      Pages 427-453
    3. Juan A. Subirana
      Pages 455-473
    4. Kenneth C. Holmes
      Pages 475-505
  5. Back Matter
    Pages 507-530

About this book

Introduction

Structural biology is undergoing a revolution in both the sophistication of new biophysical methods and the complexity of problems in biomolecular structure and organization opened up for study. These changes are directly attributable to major advances in computer technology, computational methods, development of high­ intensity synchrotron radiation sources, new magnetic resonance methods, laser optical techniques, etc. Structure-function problems previously considered intractable may now be solved. As this area of specialisation continues to expand, there is a need to review the various physical methods currently being used and developed in struc­ tural molecular biology. At the same time that individual techniques and their applications become more specialized, the need for effect­ ive communication between investigators gains in imperative. It is vital to forge links among sub-disciplines and to emphasise the complementary nature of results observed by different biophysical methods. This publication contains the review lectures given at a meeting on "Current Methods in Structural Molecular Biology" spon­ sored by NATO as an Advanced Study Institute and by FEBS ~s Advanced Course No. 78. The aim of the meeting was to bring together, in a teaching environment, students and specialists in diverse biophysical methodologies with the specific purpose of exploring, questioning and critically assessing the present and future state of biological structure research. The scientific content of the interdisciplinary Study Institute centred around three interrelated aspects; biophysical methods and instrumentation, their application to biological structure problems, and derivation of structural information and insights.

Keywords

biology development magnetic resonance molecular biology structural biology

Editors and affiliations

  • David B. Davies
    • 1
  • Wolfram Saenger
    • 2
  • Steven S. Danyluk
    • 3
  1. 1.University of BirkbeckLondonEngland
  2. 2.Free University of BerlinWest BerlinFederal Republic of Germany
  3. 3.Domtar Inc.SennevilleCanada

Bibliographic information