Composition and Function of Cell Membranes

Application to the Pathophysiology of Muscle Diseases

  • Stewart Wolf
  • Allen K. Murray

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 140)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Stewart Wolf, Allen K. Murray
    Pages 1-53
  3. Stewart Wolf, Allen K. Murray
    Pages 55-106
  4. Stewart Wolf, Allen K. Murray
    Pages 107-135
  5. Stewart Wolf, Allen K. Murray
    Pages 137-186
  6. Stewart Wolf, Allen K. Murray
    Pages 211-259
  7. Back Matter
    Pages 261-287

About this book


The present volume contains the edited transcript of a Totts Gap Colloquium held May 19-21, 1980 sponsored by the Muscular Dystrophy Association. The aim of the colloquium was to bring into focus data relating to cell membranes that might contribute to understanding the pathogenic mechanism of Duchenne muscular dystrophy. A major impediment to progress in understanding the patho­ genesis of muscular dystrophy has been the failure, so far, to identify the basic genetic defect. Pending the identification of the genetic lesion in Duchenne dystrophy and, in view of scattered but persistent indications of a basic membrane disturbance, it seemed worthwhile to explore in open dialogue the current state of knowledge of membrane morphology and chemistry with an eye to possible leads for further investigation. The participants, drawn from a variety of interested disciplines, attempted to synthesize and reconcile their findings and to identify crucial areas of ignorance in need of exploration. For the most part they avoided specialized jargon and spoke in a language that could be understood by the rest of the group. Apart from providing a review of widely varying approaches to the study of the composition and behavior of cell membranes, the discussions brought together current think~g on strategies and approaches to the study of the pathogenesis of muscular dystrophy. Already the personal contacts made at the colloquium have led to new inter-institutional collabora­ tive investigations.


behavior cell cell membrane chemistry membrane membrane transport morphology muscle pathogenesis pathophysiology physiology regulation

Editors and affiliations

  • Stewart Wolf
    • 1
    • 2
    • 3
  • Allen K. Murray
    • 4
  1. 1.St. Luke’s HospitalBethlehemUSA
  2. 2.Temple UniversityPhiladelphiaUSA
  3. 3.Scientific Advisory CommitteeMuscular Dystrophy AssociationUSA
  4. 4.Muscular Dystrophy AssociationNew YorkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1981
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-4114-7
  • Online ISBN 978-1-4684-4112-3
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site