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DNA Repair and Mutagenesis in Eukaryotes

  • Book
  • © 1980

Overview

Editors:
  1. W. M. Generoso

    1. Oak Ridge National Laboratories, Oak Ridge, USA

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  2. M. D. Shelby

    1. National Institute of Environmental Health Sciences, Research Triangle Park, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. F. J. Serres

    1. National Institute of Environmental Health Sciences, Research Triangle Park, USA

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Part of the book series: Basic Life Sciences (BLSC, volume 15)

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Table of contents (31 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Reviews

    1. Relationship Between Repair Processes and Mutation Induction in Bacteria

      • R. F. Kimball
      Pages 1-23

    2. Role of Cellular Systems in Modifying the Response to Chemical Mutagens

      • B. Strauss, K. N. Ayres, K. Bose, P. Moore, R. Sklar, K. Tatsumi
      Pages 25-43

    3. DNA Repair Pathways

      • R. B. Setlow
      Pages 45-54

  3. Lower Eukaryotes

    1. Neurospora crassa

      1. Mutagen-Sensitive Mutants in Neurospora
        • Alice L. Schroeder, Loree D. Olson
        Pages 55-62
      2. Nucleases and their Control in Wild-Type and <u>nuh</u> Mutants of Neurospora
        • M. J. Fraser, T. Y.-K. Chow, E. Käfer
        Pages 63-74
      3. Mutation-Induction in Repair-Deficient Strains of Neurospora
        • Frederick J. de Serres
        Pages 75-84

  4. Drosophila

    1. Isolation and Characterization of Repair-Deficient Mutants of Drosophila melanogaster

      • P. Dennis Smith, Ronald D. Snyder, Ruth L. Dusenbery
      Pages 175-188

    2. Effects of Recombination-Deficient and Repair-Deficient Loci on Meiotic and Mitotic Chromosome Behavior in Drosophila Melanogaster

      • Bruce S. Baker, Maurizio Gatti, Adelaide T. C. Carpenter, Sergio Pimpinelli, David A. Smith
      Pages 189-208

    3. Biochemical Characterization of Repair-Deficient Mutants of Drosophila

      • James B. Boyd, Paul V. Harris, Christopher J. Osgood, Karen E. Smith
      Pages 209-221

    4. Mutation Induction in Repair-Deficient Strains of Drosophila

      • F. E. Würgler, U. Graf
      Pages 223-240

    5. Repair and Mutagenesis in Drosophila: A Summary and Perspective

      • M. M. Green
      Pages 241-243
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Keywords

About this book

Not many years ago most discussion of mutation induction by physical and chemical agents concentrated on the initial lesions induced in the DNA with the implicit assumption that once the lesions were made they were converted almost automatically to mutations by relatively simple processes associated with DNA replication. The discovery of a variety of enzymatic processes that can repair these lesions, the great increase in our understanding of the molecular steps involved in repair, replication, and recombination, and the increasing availability of cells with genetic defects in these pro­ cesses have led to the realization that mutation induction is a far more complex process than we originally thought. Repair systems can remove lesions before they can be converted to mutation, they can also convert initial lesions to secondary ones that are them­ selves mutagenic, and they can remove potentially lethal lesions at the expense of making mutations. The error-avoiding systems asso­ ciated with replication are themselves complex and may be caused to make mistakes in various ways. These different pathways for mutation production and mutation avoidance are still being worked out in prokaryotes and are less well understood in eukaryotes. This symposium shows, however, that very encouraging progress has been made in the last several years, and the progress is now accelerating.

Editors and Affiliations

  • Oak Ridge National Laboratories, Oak Ridge, USA

    W. M. Generoso

  • National Institute of Environmental Health Sciences, Research Triangle Park, USA

    M. D. Shelby, F. J. Serres

Bibliographic Information

  • Book Title: DNA Repair and Mutagenesis in Eukaryotes

  • Editors: W. M. Generoso, M. D. Shelby, F. J. Serres

  • Series Title: Basic Life Sciences

  • DOI: https://doi.org/10.1007/978-1-4684-3842-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1980

  • Softcover ISBN: 978-1-4684-3844-4Published: 14 June 2012

  • eBook ISBN: 978-1-4684-3842-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 458

  • Topics: Human Genetics

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