Genetic Disorders and the Fetus

Diagnosis, Prevention, and Treatment

  • Aubrey Milunsky

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Aubrey Milunsky
    Pages 1-17
  3. Aubrey Milunsky
    Pages 19-46
  4. Aubrey Milunsky
    Pages 47-74
  5. Aubrey Milunsky
    Pages 75-91
  6. Aubrey Milunsky
    Pages 157-208
  7. Barbara K. Burton, Albert B. Gerbie, Henry L. Nadler
    Pages 369-377
  8. Aubrey Milunsky
    Pages 379-430
  9. Stuart Campbell
    Pages 431-467
  10. N. Thorne Griscom
    Pages 469-499
  11. Maurice J. Mahoney, John C. Hobbins
    Pages 501-526
  12. Samuel A. Rhine, Aubrey Milunsky
    Pages 527-539
  13. Jim Schröder, Leonard A. Herzenberg
    Pages 541-555
  14. Fredric D. Frigoletto Jr., Irving Umansky
    Pages 557-568
  15. André J. Nahmias, Aarolyn M. Visintine
    Pages 569-585
  16. Richard H. Schwarz
    Pages 587-602
  17. Philip R. Reilly, Aubrey Milunsky
    Pages 603-620
  18. John C. Fletcher
    Pages 621-635
  19. Mark S. Thompson
    Pages 637-660
  20. Back Matter
    Pages 661-704

About this book


Technological advances continue to expand the number of genetic disorders that can be diagnosed in utero. Utilization of this new technology has de­ manded special expertise available in relatively few academic centers. As these new applications have become more widespread so have the realities of the medicolegal implications. Notwithstanding the laboratory challenges, most legal action, at least in the United States, has arisen from the physician's failure to inform a patient about the risks of a genetic disorder or the oppor­ tunities presented by prenatal diagnosis. Hence an extensive thorough reex­ amination of the subject seems appropriate and timely. The steady escalation in the number of prenatal genetic studies now being done in the western world makes it imperative for the physician to have a thorough comprehension of the subject in its entirety. I am, therefore, fortu­ nate in having colleagues who as acknowledged experts have shared their knowledge and experience in order to make this volume a major critical repository of facts and guidance about prenatal genetic diagnosis. The subject matter ranges from a consideration of required genetic counseling through the intricacies of establishing prenatal diagnoses. Special attention is focused on new advances using ultrasound, a-fetoprotein, fetoscopy, and first trimester diagnosis. Both ethical and legal implications are discussed in detail, as is the development of public policy.


Laboratory Termination Xeroderma pigmentosum attention chromosome counseling development diagnosis ethics genes prenatal diagnosis protein ultrasound

Editors and affiliations

  • Aubrey Milunsky
    • 1
    • 2
    • 3
  1. 1.Department of PediatricsHarvard Medical SchoolBostonUSA
  2. 2.Genetics DivisionEunice Kennedy Shriver CenterWalthamUSA
  3. 3.Children’s ServiceMassachusetts General HospitalBostonUSA

Bibliographic information