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Hemoglobin and Red Cell Structure and Function

Proceedings of the Second International Conference on Red Cell Metabolism and Function held at the University of Michigan Ann Arbor, April 27–29, 1972

  • George J. Brewer

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 28)

Table of contents

  1. Front Matter
    Pages i-xxxii
  2. Hemoglobin Structure and Function

  3. Red Cell Metabolism and Function

    1. Front Matter
      Pages 77-77
    2. John W. Eaton, Martin Boraas, Nina L. Etkin
      Pages 121-131
    3. Harry Jacob, Yoshihito Yawata, Robert Howe
      Pages 133-143
  4. Carbonic Anhydrase and Carbon Dioxide Transport

  5. Sickle Cell Structure and Function

    1. Front Matter
      Pages 237-237
    2. James M. Manning, Anthony Cerami, Peter N. Gillette, Frank G. de Furia, Denis R. Miller
      Pages 253-260
    3. Peter N. Gillette, Charles M. Peterson, James M. Manning, Anthony Cerami
      Pages 261-278
    4. Lorraine M. Kraus, Asri Rasad, Alfred P. Kraus
      Pages 279-296
    5. Michael C. Jensen, H. Franklin Bunn, George C. Halikas, David G. Nathan
      Pages 297-302
    6. Jeanne M. Lusher, Marion I. Barnhart
      Pages 303-323
    7. Hyram Kitchen, W. Jape Taylor
      Pages 325-336
    8. Haig H. Kazazian Jr., Michael M. Kaback, Andrea P. Woodhead, Claire O. Leonard, William S. Nersesian
      Pages 337-346
  6. Adaptation to Hypoxia

    1. Front Matter
      Pages 347-347
    2. Fred J. Oelshlegel Jr., George J. Brewer, John A. Penner, Eric B. Schoomaker
      Pages 377-396
    3. Lorna Grindlay Moore, George J. Brewer, Fred J. Oelshlegel Jr.
      Pages 397-413
    4. D. R. Harkness, S. Roth, P. Goldman, M. Goldberg
      Pages 415-430
  7. The Effect of Oxygen Affinity on Oxygen Transport: Blood Storage

    1. Front Matter
      Pages 431-431
    2. S. Balcerzak, J. Guy, E. Metz, P. Bromberg
      Pages 433-447
    3. C. Robert Valeri, Charles G. Zaroulis
      Pages 457-477
    4. Grant R. Bartlett
      Pages 479-494
  8. Back Matter
    Pages 517-526

About this book

Introduction

Hemoglobin and the red cell have continued to set a dizzying pace as the objects of research in the two and one-half year interval since the First International Conference on Red Cell Metabolism and Function. Most exciting perhaps, is a beginning molecular attack on sickle cell disease. The story of the inter­ action of red cell metabolism and oxygen transport has continued to unfold, and we can now infer that patients with hypoxia usually utilize red cell metabolic adjustments to improve oxygenation. This puts the red cell squarely in the center of medical practice, since much of medicine-heart, pulmonary, and blood disease- deals with inadequate oxygenation. On April 27th through the 29th, 1972, crystallographers, chemists, biochemists, physiologists, geneticists, and physi­ cians from many medical disciplines met in the Towsley Center for Continuing Medical Education at the University of Michigan, Ann Arbor to present new data, to review recent developments, and to try to piece together additional features of the red cell puzzle. The meeting was dedicated to Dr. Francis John Worsley Roughton, Professor Emeritus of Colloid Science, University of Cambridge, England, in recognition of his numerous excellent contributions to the understanding of hemoglobin and red cell function. The program got off to a good start with a paper from M. F. Perutz, Nobel Laureate, on the structure of hemoglobin. Dr.

Keywords

anemia blood cell cognition development education hypoxia medical education medical practice medicine metabolism patients research transport

Editors and affiliations

  • George J. Brewer
    • 1
  1. 1.Department of Human Genetics and Medicine (Simpson Memorial Institute)University of MichiganAnn ArborUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-3222-0
  • Copyright Information Springer-Verlag US 1972
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-3224-4
  • Online ISBN 978-1-4684-3222-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site