Molecular Mechanisms for Repair of DNA

Part A

  • Philip C. Hanawalt
  • Richard B. Setlow

Part of the Basic Life Sciences book series

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Repairable Damage in DNA

  3. Enzymatic Photoreactivation

    1. Front Matter
      Pages 71-71
    2. Claud S. Rupert
      Pages 73-87
    3. Walter Harm
      Pages 89-101
    4. Betsy M. Sutherland
      Pages 107-113
    5. Milton P. Gordon
      Pages 115-121
  4. Dark Repair in Bacteriophage Systems

    1. Front Matter
      Pages 123-123
    2. Errol C. Friedberg
      Pages 125-133
    3. M. Sekiguchi, K. Shimizu, K. Sato, S. Yasuda, S. Ohshima
      Pages 135-142
    4. Hillard Berger, Wendy C. Benz
      Pages 149-154
    5. Raymond Devoret, Manuel Blanco, Jacqueline George, Miroslav Radman
      Pages 155-171
  5. Enzymology of Excision-Repair in Bacteria

    1. Front Matter
      Pages 173-173
    2. Lawrence Grossman
      Pages 175-182
    3. Andrew Braun, Peggy Hopper, Lawrence Grossman
      Pages 183-190
    4. David A. Goldthwait, Dollie Kirtikar, Sheik M. Hadi, Errol C. Friedberg
      Pages 191-196
    5. Gary F. Strniste, Susan S. Wallace
      Pages 201-204
    6. Dennis G. Uyemura, E. B. Konrad, I. R. Lehman
      Pages 209-211
    7. Barry W. Glickman
      Pages 213-218
    8. John W. Chase, Charles C. Richardson
      Pages 225-234
    9. Lester D. Hamilton, Inga Mahler, Lawrence Grossman
      Pages 235-243
    10. Warren E. Masker, Thomas J. Simon, Philip C. Hanawalt
      Pages 245-254
  6. Repair by Genetic Recombination in Bacteria

About this book


An "age" has passed in the 40 years since we first observed recovery from radiation damage in irradiated bacteria. During the early 1930s, we had been discussing the possibility of rapid changes after radiation exposure with Farring­ ton Daniels, Benjamin Duggar, John Curtis, and others at the University of Wisconsin. After working with living cells, we had concluded that organisms receiving massive insults must have a wide variety of repair mechanisms available for restoration of at least some of the essential properties of the cell. The problem was how to fmd and identify these recovery phenomena. At that time I was working on a problem considered to be of great importance-the existence of the so-called mitogenetic rays. Several hundred articles and a score of books had already appeared dealing with mitogenetic rays, a type of radiation that was thought to exist in the shorter ultraviolet region. Our search for mitogenetic rays necessitated the design of experiments of greatest sensitivity for the detection of ultraviolet. It was vital that conditions be kept as constant as possible during exposure. All the work was done at icewater temperature (3-5°C) during and after exposure. We knew that light was an important factor for cell recovery, so all our experiments were done in dim light, with the plated-out cells being covered with dark cloth. Our statements on the effect of visible light stimulated Kelner to search for "photoreactivation' (as it was later called).


Activation Mammalia Recovery bacteria cell cells experiment molecular mechanisms radiation temperature ultraviolet

Editors and affiliations

  • Philip C. Hanawalt
    • 1
  • Richard B. Setlow
    • 2
  1. 1.Department of BiologyStanford UniversityUSA
  2. 2.Biology DepartmentBrookhaven National LaboratoryUSA

Bibliographic information