Temporal Aspects of Therapeutics

  • John Urquhart
  • F. Eugene Yates

Part of the ALZA Conference Series book series (ALZA, volume 2)

Table of contents

  1. Front Matter
    Pages i-x
  2. Introduction

    1. John Urquhart, F. Eugene Yates
      Pages 1-1
  3. Temporal Organization in Biosystems

    1. Front Matter
      Pages 3-3
    2. Harold J. Morowitz
      Pages 5-15
    3. F. E. Yates, A. S. Iberall
      Pages 17-34
    4. Arthur T. Winfree
      Pages 35-57
  4. Temporal Aspects of Subcellular Synthesis

    1. Front Matter
      Pages 59-59
    2. Dale Kaiser
      Pages 61-70
  5. Temporal Aspects of Organ System Function

  6. Temporal Patterns and Therapeutics

    1. Front Matter
      Pages 105-105
    2. Walter J. Meyer III, Catherine S. Delea, Frederic C. Bartter
      Pages 143-163
    3. L. L. Ewing, C. Desjardins, L. G. Stratton
      Pages 165-180
    4. J. S. Soeldner, K. W. Chang, S. Aisenberg, John M. Hiebert
      Pages 181-207
    5. John Urquhart, F. Eugene Yates
      Pages 209-210
  7. Back Matter
    Pages 211-213

About this book


Drugs are molecular agents of a physician's purpose. Discussions of their mechanisms of action center upon biochemical processes, even though the therapeutic intent may be to create an effect at a higher level of organization. We often prescribe to stop pain, increase vigor, assure sleep, curtail infection, alleviate inflammation, elevate mood, etc. To achieve rational therapy at high levels of organization it is not enough to know the molecular structures of drugs, and the points at which they couple into biochemical reaction chains. Such knowledge deals with static concepts, whereas the biosystems we treat extend in the dimensions of time as well as in those of space. Even when "resting", a biosystem manifests a dynamic stability, and sustains numerous processes whose successive states follow trajectories in time. A chemical message is not necessarily received by a biosystem as the same signal at one time as at another. Studies of cell cycle biochemistry, and of circadian variations in toxicity of some agents, have emphasized the importance of time as an aspect of therapeutics. In this volume, temporal aspects of living systems are considered. In the first section they are dealt with from the point of view of general design principles, in three papers by Morowitz, by Yates and Iberall, and by Winfree. In the second section, papers by Kaiser and by Thompson present accounts of sequential events in fundamental subcellular processes.


biochemistry cancer cell chemotherapy drug drug delivery infection inflammation organizations pain pharmacokinetics pharmacology sleep therapy toxicity

Editors and affiliations

  • John Urquhart
    • 1
  • F. Eugene Yates
    • 1
    • 2
  1. 1.ALZA CorporationPalo AltoUSA
  2. 2.Department of Biomedical EnngineeringUniversity of Southern CalifornisLos AngelesUSA

Bibliographic information