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Radiotherapy, Surgery, and Immunotherapy

  • Frederick F. Becker

Part of the Cancer book series (C, volume 6)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Radiotherapy

    1. Front Matter
      Pages 1-1
    2. Robert J. Shalek
      Pages 39-50
    3. M. M. Elkind, J. L. Redpath
      Pages 51-99
    4. J. Denekamp, J. F. Fowler
      Pages 101-137
    5. J. F. Fowler, J. Denekamp
      Pages 139-180
    6. G. E. Adams
      Pages 181-223
    7. Robert F. Kallman, Sara Rockwell
      Pages 225-279
    8. Eric J. Hall
      Pages 281-315
    9. Milan Potmesil, Joseph LoBue, Anna Goldfeder
      Pages 317-398
  3. Surgery

    1. Front Matter
      Pages 399-399
  4. Immunotherapy

    1. Front Matter
      Pages 423-423
    2. Evan M. Hersh, G. M. Mavligit, J. U. Gutterman, S. P. Richman
      Pages 425-532
  5. Back Matter
    Pages 533-544

About this book

Introduction

The history of the development of cancer therapy has been marked by a recurring pattern, one of initially exciting and encouraging results as new methods were introduced, followed by dismaying failures. The extremity of the disease and its high mortality have dictated that each means of damaging tumor cells would be rapidly explored and exploited as a mode of therapy, long before the correspond­ ing theory and technique were completely understood and perfected. Thus radiation was used as an antitumor agent almost immediately following recogni­ tion of its cytodestructive capability. Equally constant, following the rapid utilization of new therapeutic methods, has been a period of significant technical improvements. This second aspect of the pattern is also illustrated by the field of radiotherapy. New radiation sources, new methods of dosimetry, use of high-energy radiation, and other new techniques allowed the therapist to better focus upon the tumor and to improve the geometry of exposure. Thus, with each technical advance, the "reach" of radiotherapy was increased and damage to normal tissues was decreased. Inevitably, however, a limit was reached, a point at which clinicians and researchers realized they could go no further without returning to a more fundamental search, one based on the biology of the tumor cell itself.

Keywords

cancer cell dosimetry immunotherapy mortality radiation radiotherapy surgery tumor

Editors and affiliations

  • Frederick F. Becker
    • 1
  1. 1.M. D. Anderson Hospital and Tumor InstituteUniversity of Texas System Cancer CenterHoustonUSA

Bibliographic information