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Cancer a Comprehensive Treatise 2

Etiology: Viral Carcinogenesis

  • Frederick F. Becker
Book

Part of the Cancer book series (C, volume 2)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. RNA Viruses

    1. Front Matter
      Pages 1-1
    2. J. Michael Bishop, Harold E. Varmus
      Pages 3-48
    3. Hidesaburo Hanafusa
      Pages 49-90
    4. Michael M. Lieber, George J. Todaro
      Pages 91-130
    5. Dan H. Moore
      Pages 131-167
  3. DNA Viruses

    1. Front Matter
      Pages 207-207
    2. F. Rapp, M. A. Jerkofsky
      Pages 209-239
    3. Yohei Ito
      Pages 323-341
    4. George Khoury, Norman P. Salzman
      Pages 343-427
  4. Back Matter
    Pages 429-439

About this book

Introduction

The impact of basic research on oncology has been particularly impressive in the recent search for the cause of malignancy. Equally impressive is our appreciation of the cause of tumors based on observation. Even in the earliest era of the study of infectious diseases, it was proposed that tumorous growth in animals and birds resulted from "minute" infectious particles. Experiments then supported the hypothesis, that the etiologic agent in many animal tumors was viral. The development of molecular biology, supported by technical advances and conceptual understanding of macromolecular action, led to an explosive increase in studies of animal oncogenic viruses. For a decade, new findings emerged from research laboratories revealing the enormous variety of such agents, the complex­ ity of their interactions with cells, and the tantalizingly possible mechanisms by which they might cause malignant transformation of the cell. Repeatedly, clues emerged which suggested the intervention of viral agents in human tumors. A breathless excitement pervaded both the scientific and public communities as highly publicized findings rapidly followed one another. The excitement was no less scientific than it was practical, for implicit in the concept of the viral oncogen is the possibility of specific virostatic or virotoxic agents or of immunization.

Keywords

DNA carcinogenesis cell etiology leukemia molecular biology oncology tumor tumorigenesis

Editors and affiliations

  • Frederick F. Becker
    • 1
  1. 1.New York University School of MedicineNew YorkUSA

Bibliographic information