Paget’s Disease of Bone

Clinical Assessment, Present and Future Therapy Proceedings of the Symposium on the Treatment of Paget’s Disease of Bone, held October 20, 1989 in New York City

  • Frederick R. Singer
  • Stanley Wallach

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Alex Norman
    Pages 1-19
  3. Stephen M. Krane
    Pages 20-28
  4. Steven L. Teitelbaum
    Pages 29-43
  5. Frederick R. Singer, Karla Ginger
    Pages 75-85
  6. Pierre J. Meunier, Alain Ravault
    Pages 86-99
  7. Olav L. M. Bijvoet
    Pages 100-111
  8. John A. Kanis, Eugene V. McCloskey, Declan O’Doherty, Neveen A. T. Hamdy, Derek Bickerstaff, Monique Beneton et al.
    Pages 112-134
  9. Charles Nagant de Deuxchaisnes, Jean-Pierre Devogelaer
    Pages 135-165
  10. Peter Burckhardt, D. Thiébaud
    Pages 166-175
  11. Stephen M. Krane, Susan F. Kroop
    Pages 191-199
  12. Frederick S. Kaplan
    Pages 200-213
  13. Back Matter
    Pages 215-313

About this book


Paget's disease is an old disease historically, but a new disease therapeutic­ ally. Human remains unearthed in Lancashire, England, dating from ap­ proximately 900 AD, show clear evidence of the aftliction. However, it was not until the 1800s that physicians rediscovered the condition, and a little more than 100 years ago that Sir James Paget published a perceptive and accurate description of the disease from the clinical and pathologic points of view. He felt the disease represented an inflammatory condition of the skeleton and hence named it osteitis deformans. The condition again lapsed into anonymity for several decades afterwards, and therapeutic approaches did not evolve until after World War II when several groups, located mainly in the Boston area, began using a variety of agents, includ­ ing corticosteroids for treatment of this condition. These early attempts at therapy were unsuccessful and the condition remained essentially untreat­ able until the development of the calcitonins and the bisphosphonates in the 1970s. In 1978, the Paget's Disease Foundation, a private nonprofit volun­ tary health agency, was founded to assist individuals aftlicted by Paget's disease of bone, to provide education regarding this condition to the medical community, and to encourage research efforts to better under­ stand and treat the condition. An international conference was organized under the aegis of the Paget's Disease Foundation and was held in New York City in October, 1989, ten years after the founding of the Paget's Disease Foundation.


bisphosphonates bone development education health inflammation research skeleton steroid steroids therapy treatment

Editors and affiliations

  • Frederick R. Singer
    • 1
    • 2
  • Stanley Wallach
    • 3
  1. 1.UCLA School of MedicineUniversity of California at Los AngelesUSA
  2. 2.Bone CenterCedars-Sinai Medical CenterLos AngelesUSA
  3. 3.Department of Internal MedicineUniversity of South Florida College of MedicineTampaUSA

Bibliographic information