Membrane Structure and Mechanisms of Biological Energy Transduction

  • J. Avery

Table of contents

  1. Front Matter
    Pages i-vi
  2. Mechanisms of Biological Energy Transduction

    1. Front Matter
      Pages N1-N3
    2. Albert Szent-Gyorgyi
      Pages 1-4
    3. Alexander Tzagoloff
      Pages 39-45
    4. Gustavo Viniegra-Gonzalez, Manuel F. Morales
      Pages 55-64
    5. Ichiji Tasaki, Mark Hallett
      Pages 65-79
    6. Y. Hatefi, W. G. Hanstein
      Pages 129-136
  3. Membrane Structure

    1. Front Matter
      Pages N4-N4
    2. Lars Ernster, Kerstin Juntti, Kouichi Asami
      Pages 351-361
    3. D. D. Eley, R. J. Mayer, R. Pethig
      Pages 389-402
    4. W. J. Lennarz, Malka G. Scher
      Pages 441-453
    5. D. E. Green, S. Ji, R. F. Brucker
      Pages 527-558
    6. B. W. W. Grout, J. H. M. Willison, E. C. Cocking
      Pages 585-602

About this book


The problem of electron transfer phosphorylation was first formu­ lated in 1939 by Belitser and Tsibakova I who introduced the "P: 0" criterion and showed that this ratio is more than 1. The authors noted that such a high value of the phosphorylation coefficient suggests a fundamental difference in the mechanisms of A TP formation coupled with respiration, and glycolysis, since in the latter case, the amount of the ATP synthesized is equal to that of the substrate utilized. A lot of hypothetical schemes were put forward to explain the nature of coupling between electron transfer and phosphorylation, but none of them solved the problem. Only quite recently, one hypo­ thetical scheme of energy coupling, viz. Mitchell's chemiosmotic concept, 2.3 was supported by experimental data which allow us to prefer it to alternative possibilities. In this paper, I shall try to substantiate the statement that oxidation and phosphorylation can be coupled via a membrane potential as was postulated by Mitchell.


ATP Lipid Oxidation cell membrane energy enzyme enzymes metabolism mitochondria phosphorylation photosynthesis protein protoplasts respiration synthesis

Editors and affiliations

  • J. Avery
    • 1
  1. 1.Department of ChemistryImperial College of Science and TechnologyLondon S.W.7England

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