Mechanisms in Fibre Carcinogenesis

  • Robert C. Brown
  • John A. Hoskins
  • Neil F. Johnson

Part of the NATO ASI Series book series (NSSA, volume 223)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. The Carcinogenicity of Mineral Fibres

    1. Front Matter
      Pages 1-1
    2. Human studies

    3. Animal studies

  3. Chemical and Physical Properties

    1. Front Matter
      Pages 101-101
    2. Fibre Size and Chemistry

      1. R. C. Brown, J. A. Hoskins, E. A. Sara, C. E. Evans, K. J. Cole
        Pages 115-120
      2. K. Donaldson, S. Szymaniec, X. Y. Li, D. M. Brown, G. M. Brown
        Pages 121-130
      3. David B. Warheit, Kimberly A. Moore, Michael C. Carakostas, Mark A. Hartsky
        Pages 143-156
      4. H. Muhle, B. Bellmann, F. Pott
        Pages 181-187
      5. J. Young, J. J. Laskowski, R. Acheson, S. D. Forder
        Pages 189-197
      6. T. C. Pederson, C. A. Powell, J. Santrock, L. Rosenbaum, J. Siak, G. G. Tibbetts et al.
        Pages 199-212
    3. Minerology

      1. R. P. Nolan, A. M. Langer, G. W. Oechsle, J. Addison, D. E. Colflesh
        Pages 231-251
      2. Antonella Astolfi, Bice Fubini, Elio Giamello, Marco Volante, Elena Belluso, Giovanni Ferraris
        Pages 269-283
  4. Mechanisms of Pathogenesis

    1. Front Matter
      Pages 285-285
    2. Genotoxic effects

      1. Marie-Claude Jaurand
        Pages 287-307
      2. Tom K. Hei, Zhu Y. He, Chang Q. Piao, Charles Waldren
        Pages 319-325
      3. Kaija Linnainmaa, Katarina Pelin-Enlund, Kaarina Jantunen, Esa Vanhala, Timo Tuomi, Jim Fitzgerald et al.
        Pages 327-334
    3. Effects on Gene Expresssion

      1. Yvonne M. W. Janssen, Joanne P. Marsh, Paul J. A. Borm, Piyawan Surinrut, Kaaren Haldeman, Brooke T. Mossman
        Pages 359-365
      2. Cheryl Walker, Edilberto Bermudez, Wendy Stewart, Jeff Everitt
        Pages 377-383
    4. Fibres and free radicals

    5. Other effects and promotion

  5. Human Risk Assessment

    1. Front Matter
      Pages 513-513

About this book


The Editors are sorry that the production of this volume was delayed by the ill­ health of one of them and we hope that this does not detract from the value of the con­ tents. For once this delay is not the fault of any of the authors only the editors are to blame. Many of the workers in the field of fibre toxicology became convinced by the middle 1980's that the worst of the furore over asbestos was over although we were left with an intriguing problem - how does asbestos cause disease? It was expected that the future impact of fibres on human health would be very small since asbestos exposure would be controlled and there was little chance that man-made fibres would prove haz­ ardous. These man-made fibres are much thicker than asbestos and, in most cases, they are less durable in the body. Both of these properties are believed to make them much less likely to cause disease. However many of us had fallen into the habit of calling these materials "asbestos substitutes" and thus they have acquired a little of the notoriety at­ tached to the natural fibrous minerals. Very few of these man-made fibres are actually used as replacements for asbestos. Asbestos was not suitable for the uses to which the insulation wools are usually put and the ceramic fibres are replacements for fire brick not asbestos which is destroyed at the temperatures at which these materials are used.


Pathogene carcinogenesis cell gene expression mesothelioma pathogenesis toxicity toxicology

Editors and affiliations

  • Robert C. Brown
    • 1
  • John A. Hoskins
    • 1
  • Neil F. Johnson
    • 2
  1. 1.Medical Research Council Toxicology UnitCarshalton, SurreyUK
  2. 2.Inhalation Toxicology Research InstituteAlbuquerqueUSA

Bibliographic information