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Lipoprotein Deficiency Syndromes

  • Aubie Angel
  • Jiri Frohlich

Part of the Advances in Experimetal Medicine and Biology book series (AEMB, volume 201)

Table of contents

  1. Front Matter
    Pages i-x
  2. Lipoprotein Deficiency and Atherosclerosis

    1. Ernst J. Schaefer, Judith R. McNamara, Carol J. Mitri, Jose M. Ordovas
      Pages 1-15
    2. Ronald M. Krauss, Alex V. Nichols
      Pages 17-27
    3. John P. Kane
      Pages 29-35
    4. Bessie Fong, Andrew Salter, Jose Jimenez, Jean-Pierre Despres, Aubie Angel
      Pages 61-66
  3. Hypoalphalipoproteinemia Syndromes

    1. Charles J. Glueck, Marc A. Melser, I. B. Borecki, Jane L. H. C. Third, D. C. Rao, Peter M. Laskarzewski
      Pages 83-92
    2. C. Vergani, A. L. Catapano, A. Sidoli
      Pages 93-103
    3. Jean Davignon, A. Christine Nestruck, Petar Alaupovic, Daniel Bouthillier
      Pages 111-125
    4. G. R. Thompson, A. Jadhav
      Pages 127-135
    5. Robert A. Norum, Trudy M. Forte, Petar Alaupovic, Henry N. Ginsberg
      Pages 137-149
    6. Simon W. Law, Karl J. Lackner, Silvia S. Fojo, Ashok Hospattankar, Juan C. Monge, H. Bryan Brewer Jr.
      Pages 151-162
  4. LCAT and Cholesterol Transport

    1. Yves L. Marcel, Camilla A. Vézina, Philip K. Weech, François Tercé, Ross W. Milne
      Pages 163-179
    2. Jiri Frohlich, Roger McLeod
      Pages 181-194
    3. George H. Rothblat, Michael C. Phillips
      Pages 195-204
  5. Hypertriglyceridemia Secondary to Enzyme or Apoprotein Deficiency

    1. W. Carl Breckenridge
      Pages 211-226
    2. John D. Brunzell, Per-Henrik Iverius, Mark S. Scheibel, Wilfred Y. Fujimoto, Michael R. Hayden, Roger McLeod et al.
      Pages 227-239
    3. M. R. Hayden, C. Vergani, S. E. Humphries, L. Kirby, R. Shukin, R. McLeod
      Pages 241-251
    4. J. Alick Little, Philip W. Connelly
      Pages 253-260
    5. Thomas L. Innerarity, David Y. Hui, Thomas P. Bersot, Robert W. Mahley
      Pages 273-288
  6. Back Matter
    Pages 299-303

About this book

Introduction

Current interest in lipoprotein deficiency states stems from the growing realization of their importance in the etiology of premature coronary heart disease. While hypercholesterolemia and coronary heart disease risk are strongly correlated in their etiologic relationship, it is becoming equally clear that deficiencies in HDL, whether congenital or acquired, also enhance the risk for the future development of coronary atherosclerosis. This has led to renewed attention to the lipid hypothesis and realization of the fact that each lipoprotein class and apoprotein species has specific functions in the transport and cellular uptake of various lipids. It is a truism that a biochemical correlate of disease once identified is subsequently recognized with increasing frequency in clinical medicine. The story of HDL was no exception. Indeed hypoalphalipoproteinemia appears to be a disease of high prevalence approaching and perhaps even exceeding that of familial hypercholesterolemia. Its clinical signifi­ cance escaped our notice for many years largely due to a heavy emphasis on hypercholesterolemia and to difficulties in measuring HDL reliably.

Keywords

Corona Lipid biology development enzyme enzymes etiology lipoprotein medicine metabolism molecular biology protein proteins receptor transport

Editors and affiliations

  • Aubie Angel
    • 1
  • Jiri Frohlich
    • 2
  1. 1.Institute of Medical SciencesUniversity of TorontoTorontoCanada
  2. 2.Shaughnessy HospitalUniversity of British ColumbiaVancouverCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-1262-8
  • Copyright Information Springer-Verlag US 1986
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-1264-2
  • Online ISBN 978-1-4684-1262-8
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site