The Antiprogestin Steroid RU 486 and Human Fertility Control

  • Etienne-Emile Baulieu
  • Sheldon J. Segal

Part of the Reproductive Biology book series (RBIO)

Table of contents

  1. Front Matter
    Pages i-ix
  2. D. Philibert, M. Moguilewsky, I. Mary, D. Lecaque, C. Tournemine, J. Secchi et al.
    Pages 49-68
  3. M. J. Bosc, G. Germain, A. Nicolle, D. Philibert, E. E. Baulieu
    Pages 69-70
  4. J. Secchi, D. Lecaque, C. Tournemine, D. Philibert
    Pages 79-86
  5. M. Moguilewsky, D. Philibert
    Pages 87-97
  6. J. Salmon, M. Mouren
    Pages 99-101
  7. Roger Deraedt, Claude Bonnat, Monique Busigny, Pierre Chatelet, Christian Cousty, Michel Mouren et al.
    Pages 103-122
  8. Roger Deraedt, Bernard Vannier, Robert Fournex
    Pages 123-126
  9. David L. Healy, Gary D. Hodgen
    Pages 127-140
  10. Francisco J. Rojas, James L. O’Conner, Ricardo H. Asch
    Pages 141-154
  11. G. Germain, D. Philibert, J. Pottier, M. Mouren, E. E. Baulieu, C. Sureau
    Pages 155-167
  12. W. L. Herrmann, A. M. Schindler, R. Wyss, P. Bischof
    Pages 179-198
  13. Lars Birgerson, Viveca Odlind, Elof Johansson
    Pages 235-241
  14. R. Sitruk-Ware, L. Billaud, I. Mowszowicz, H. Yaneva, P. Mauvais-Jarvis, C. W. Bardin et al.
    Pages 243-248
  15. M. L. Swahn, S. Cekan, G. Wang, V. Lundstrom, M. Bygdeman
    Pages 249-258
  16. R. W. Kelly, D. L. Healy, M. J. Cameron, I. T. Cameron, D. T. Baird
    Pages 259-262
  17. Horacio B. Croxatto, Irving M. Spitz, Ana Maria Salvatierra, C. Wayne Bardin
    Pages 263-269
  18. Gilbert Schaison, Martine George, Nelly Lestrat, Etienne-Emile Baulieu
    Pages 271-278
  19. Lynnette K. Nieman, David L. Healy, Irving M. Spitz, George R. Merriam, C. Wayne Bardin, D. Lynn Loriaux et al.
    Pages 279-283
  20. Donna Shoupe, Daniel R. Mishell Jr., Maria Lacarra, Elia Gutierrez, Pekka Lahteenmaki, Irving M. Spitz
    Pages 285-293
  21. Paul Robel, Achille Gravanis, Gilbert Schaison, Martine George, Jean de Brux, Pondichery G. Satyaswaroop et al.
    Pages 295-306
  22. Henri Rochefort, Dany Chalbos
    Pages 307-314
  23. Irving M. Spitz, Charles E. Wade, Dorothy T. Krieger, Pekka Lahteenmaki, C. Wayne Bardin
    Pages 315-329
  24. R. C. Gaillard, A. Riondel, A. F. Muller, W. Herrmann, E. E. Baulieu
    Pages 331-337
  25. Lynnette K. Nieman, George P. Chrousos, Charles Kellner, Irving M. Spitz, Bruce C. Nisula, Gordon B. Cutler Jr. et al.
    Pages 339-345
  26. Etienne Baulieu, André Ulmann
    Pages 347-347
  27. Back Matter
    Pages 349-353

About this book


Advances in basic biological research have proceeded rapidly in recent years. The fields of molecular genetics and immunology have experienced dramatic breakthroughs, capturing the imagination of both the scientific community and the general public. With less public notice, receptor biology has brought a cascade of new discoveries and insights. The entire science of pharmacology has been virtually rewritten in terms of receptor phenomenology. In particular, the discovery of specific receptors for steroid and protein hormones has been of seminal importance. With this new information, we have advanced our understanding of the mechanism and specifity of hormone action. We can now explain how hormones interact selectively with specific target cells and how hormones alter biochemical events within the target cells. These facts have already impacted on applied problems of clinical medicine, particularly in diagnosis and treatment of cancer and some metabolic diseases. Now, a new and important application of basic receptor biology and chemistry looms ahead. Within a few short years since the discovery of the progesterone receptor, chemists have synthesized molecules with a greater affinity for the receptor than progesterone itself and which, while occupying the receptor, fail to trigger the events which transform a target cell from the unstimulated to the stimulated state. This is the basis of the competitive inhibitory action of the anti-progestational agent, synthesized by the chemists at Roussel Uc1af, Paris, and designated RU 486.


biology cancer cells chemistry diagnosis enology fertility fields genetics immunology information medicine pharmacology protein receptor

Editors and affiliations

  • Etienne-Emile Baulieu
    • 1
  • Sheldon J. Segal
    • 2
  1. 1.University of Paris-SudParisFrance
  2. 2.The Rockefeller FoundationNew YorkUSA

Bibliographic information