Cerebral Energy Metabolism and Metabolic Encephalopathy

  • David W. McCandless

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Richard Hawkins
      Pages 3-23
  3. Metabolic Encephalopathy Associated with Severe Interruption of Substrate

    1. Front Matter
      Pages 25-25
    2. David W. McCandless, Marc S. Abel
      Pages 27-41
    3. Gary E. Gibson
      Pages 43-78
    4. W. David Lust, Hajime Arai, Yukimasa Yasumoto, Tim S. Whittingham, Bogden Djuricic, Bogomir B. Mrsulja et al.
      Pages 79-117
  4. Metabolic Encephalopathy Resulting Primarily from Intrinsic Factors

    1. Front Matter
      Pages 119-119
    2. Roger F. Butterworth
      Pages 121-141
    3. Alexander L. Miller
      Pages 143-162
    4. Leslie Zieve, Gorig Brunner
      Pages 179-201
    5. Alan H. Lockwood
      Pages 203-227
    6. Gerard B. Odell, Henry S. Schutta
      Pages 229-261
    7. Paul E. Teschan, Allen I. Arieff
      Pages 263-285
    8. Robert C. Collins
      Pages 287-307
  5. Metabolic Encephalopathy That May Result from Extrinsic Factors

    1. Front Matter
      Pages 309-309
    2. Frederick C. Kauffman
      Pages 311-334
    3. David W. McCandless
      Pages 335-351
    4. Jean Holowach Thurston, Richard E. Hauhart, John A. Dirgo, David B. McDougal Jr.
      Pages 353-359
    5. Roderick K. Roberts, Anastacio M. Hoyumpa Jr., George I. Henderson, Steven Schenker
      Pages 361-389
    6. John J. O’Neill, David Holtzman
      Pages 391-424
    7. Richard C. Wiggins
      Pages 425-432
    8. K. W. Rammohan, A. A. Farooqui, L. A. Horrocks
      Pages 433-445
  6. Back Matter
    Pages 447-456

About this book


In recent years, there has been rapid growth in knowledge pertaining to the nervous system. This has, in some measure, been due to the development and application of a number of techniques such as the 2-deoxyglucose method and microchemical methods for measuring metabolites and regional cerebral blood flow. Data from the application of these techniques are just beginning to be collected, and the next few years promise to bring many new and exciting findings. The study of energy metabolism in brain is particularly interesting due to the fact that although the brain has scant energy reserves (as compared with the liver), it has one of the highest metabolic rates in the body. Recent studies from several laboratories have shown a surprising divergence of re­ sponses to metabolic insult in different areas of brain. In this regard, the cer­ ebellum, for example, may have metabolic features which are uniqve from those of any other region. The high-energy phosphate compounds ATP and phos­ phocreatine, supplied by the oxidative metabolism of glucose, are necessary for normal cerebral functions such as the maintenance of membrane potentials, transmission of impulses, and synthetic processes. Interruption of substrate or "poisoning" of the system by a variety of means lead to a rapid change in cellular energetics, and ultimately cell death. From the clinical standpoint, an interesting feature of metabolic encephalopathy is that in many cases, early diagnosis and treatment may result in a rapid reversal of symptoms.


Nervous System anatomy behavior cortex metabolism physiology visual evoked potential (VEP)

Editors and affiliations

  • David W. McCandless
    • 1
  1. 1.Department of Neurobiology and AnatomyUniversity of Texas Medical School at HoustonHoustonUSA

Bibliographic information