Chorionic Gonadotropin

  • Sheldon J. Segal

Table of contents

  1. Front Matter
    Pages i-ix
  2. Comparative Physiology

  3. Chemistry, Metabolism, and Immunology

    1. Steven Birken, Robert E. Canfield
      Pages 65-88
    2. William T. Moore Jr., Bruce D. Burleigh, Darrell N. Ward
      Pages 89-126
    3. Yoshinori Endo, Yoshihiko Ashitaka, Akira Kobata, Shimpei Tojo
      Pages 127-145
    4. Yoshihiko Ashitaka, Ryuichiro Nishimura, Masayuki Takemori, Shimpei Tojo
      Pages 147-175
    5. Takeshi Maruo, Sheldon J. Segal, S. S. Koide
      Pages 177-197
    6. Hao-Chia Chen, Shuji Matsuura, Masanobu Ohashi
      Pages 231-252
  4. Molecular Biology and Regulatory Genetics

    1. R. Folman, J. Ilan, N. de Groot, A. A. Hochberg
      Pages 277-294
    2. Raymond W. Ruddon, Charlotte A. Hanson, Albert H. Bryan, Carmen Anderson
      Pages 295-315
    3. Yoram Salomon, Elhanan Ezra, Abraham Nimrod, Yehudith Amir-Zaltsman, Hans R. Lindner
      Pages 345-369
  5. Evolution and Oncology

    1. Glenn D. Braunstein, Joan Rasor, Maclyn E. Wade
      Pages 383-409
    2. Christopher A. Adejuwon, Samuel S. Koide, S. M. Mitsudo, Sheldon J. Segal
      Pages 411-419
    3. S. S. Koide, T. Maruo, H. Cohen, S. J. Segal
      Pages 421-434
    4. Hernan F. Acevedo, Elizabeth A. Campbell-Acevedo, Malcolm Slifkin
      Pages 435-460
    5. S. S. Koide, T. Maruo, H. F. Acevedo, E. A. Campbell-Acevedo, M. Slifkin
      Pages 461-464
  6. Back Matter
    Pages 491-507

About this book


This volume is devoted to the chemistry, immunology, molecular biology, and physiology of the human chorionic gonadotropin, heG. For this glycoprotein molecule the course from discovery to chemical deciphering covered about fifty years. It was in 1928 that Ascheim and Zondek reported that urine from pregnant women contains something that stimulates the ovaries of mice or rats. This provided the basis for the famous A-Z test for pregnancy and for the "rabbit test" modification introduced by Friedman. As researchers sought to find more sensitive responses to heG, they used a wide variety of species including the South African aquatic toad, Xenopus Zaevis, the terrestrial toad of South America, Bufo arinarus, and the African weaver finch, EupZeetes afra. The weaver finch feather reaction was particularly noteworthy, for it disclosed a non-gonadal response to heG/LH. In retrospect, this may have been an important evolutionary clue to the realization that the designation of the hormone as a "gonadotropin" may have been only partially descriptive of the molecule's physiological function--a concept that is gaining attention, as the papers in this 1980 volume divulge.


Gonadotropin attention biology chemistry evolution hormone immunology metabolism molecular biology molecule physiology pregnancy protein protein hormones research

Editors and affiliations

  • Sheldon J. Segal
    • 1
  1. 1.The Rockefeller FoundationNew YorkUSA

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