Structure, Function, and Clinical Implications

  • Ralph A. Bradshaw
  • Stanford Wessler

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 52)

Table of contents

  1. Front Matter
    Pages i-x
  2. Structural Aspects

    1. Front Matter
      Pages 1-1
    2. Molecular Properties

      1. Roger W. Jeanloz
        Pages 3-17
      2. Edward D. T. Atkins, Ian A. Nieduszynski
        Pages 19-37
      3. Leon Yuan, Salvatore S. Stivala
        Pages 39-49
    3. Biosynthesis

      1. Jeremiah E. Silbert, Hynda K. Kleinman, Cynthia K. Silbert
        Pages 51-60
      2. Gudrun Bäckström, Anund Hallen, Magnus Höök, Leif Jansson, Ulf Lindahl
        Pages 61-77
    4. Biological Properties

    5. Analytical and Pharmacological Considerations

  3. Functional Aspects

    1. Front Matter
      Pages 193-193
    2. Effect on Blood Coagulation: Interaction with Antithrombin III

      1. E. Thye Yin, Linda Eisenkramer, Janet V. Butler
        Pages 239-242
      2. Anna D. Borsodi, Ralph A. Bradshaw, Indulal K. Rughani, Robert M. Bruce
        Pages 249-253
    3. Interaction with Platelets

      1. J. H. Joist, J. F. Mustard
        Pages 255-261
    4. Effect on Lipoprotein Lipase

      1. Thomas Olivecrona, Olle Hernell, Torbjörn Egelrud
        Pages 269-279
    5. Other Effects

      1. Jack Goldstein, Alan A. Waldman, Gerard Marx
        Pages 289-297
  4. Clinical Aspects

    1. Front Matter
      Pages 307-307
    2. Antithrombotic Efficacy

      1. Stanford Wessler
        Pages 309-322
      2. Menard M. Gertler, Hillar E. Leetma, Russell J. Koutrouby, Elyse D. Johnson
        Pages 341-350
      3. R. D. Falb, R. I. Leininger, G. Grode, J. Crowley
        Pages 365-374
    3. Toxicity

      1. Louis V. Avioli
        Pages 375-387
    4. Panel Discussion

      1. Ralph A. Bradshaw, Stanford Wessler
        Pages 389-409
  5. Back Matter
    Pages 411-422

About this book


The International Symposium on Heparin, held May 13-15, 1974, in St. Louis, Missouri, as a part of the dedication of the Shoenberg Pavilion of the Jewish Hospital of St. Louis, was conceived as a forum to bring together physicians and scientists with a basic in­ terest in the structure, function and clinical usefulness of heparin. Few naturally occurring substances have commanded the breadth of interest among members of the biomedical research community as this compound has. Aspects of its covalent and three-dimensional struc­ ture, its biosynthesis, its interaction with and effect on physio­ logically important moieties and its use as a therapeutic agent in a variety of disease states have been actively studied for the past several decades. Thus, the present state of these studies seemed to be a timely subject for discussion, not only to gather together in one place representative samples of the myriad of data on heparin but also to underscore the ever increasing necessity for communica­ tion between basic research and clinical practice.


Lipoprotein artery biomedical research biosynthesis blood embolism hospital metabolism myocardial infarction plasma platelet research thrombosis

Editors and affiliations

  • Ralph A. Bradshaw
    • 1
  • Stanford Wessler
    • 2
    • 3
  1. 1.Department of Biological ChemistryWashington University School of MedicineSt. LouisUSA
  2. 2.Department of MedicineThe Jewish HospitalSt. LouisUSA
  3. 3.Washington University School of MedicineSt. LouisUSA

Bibliographic information

  • DOI
  • Copyright Information Plenum Press, New York 1975
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-0948-2
  • Online ISBN 978-1-4684-0946-8
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site