Neurobiology of Aging

An Interdisciplinary Life-Span Approach

  • J. Mark Ordy
  • Kenneth R. Brizzee

Part of the Advances in Behavioral Biology book series (ABBI, volume 16)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Definitions, theories, methods, molecular, cellular, organ and species difference in aging

  3. Psychophysiological changes in aging

  4. Neurophysiological changes in the nervous system in aging

    1. E. Gutmann, V. Hanzlikova
      Pages 193-207
    2. R. W. Lang, D. J. Carlo
      Pages 233-251
  5. Neurochemical changes in the nervous system in aging

  6. Morphological changes in the nervous system in aging

    1. Kenneth R. Brizzee, P. Klara, J. E. Johnson
      Pages 425-461
    2. Kenneth R. Brizzee, Bernice Kaack, Peter Klara
      Pages 463-484
    3. W. Bondareff, M. Breen, H. G. Weinstein
      Pages 485-503
  7. Environmental modifiability or plasticity of the brain and neuroendocrines from maturity to senescence

    1. Albert Y. Sun, J. Mark Ordy, T. Samorajski
      Pages 505-520
    2. T. Samorajski
      Pages 521-543
  8. Neuropathology and aging

  9. Neurobiology and aging in nonhuman primates

    1. J. Mark Ordy
      Pages 575-594
  10. Back Matter
    Pages 595-603

About this book


Aging is one of the most universal and inevitable social and sci­ entific challenges confronting man. The lives of all multicellular organisms begin with conception, extend through phases of development, maturity, senescence and finally end in death. Man is no exception, but has the unique feature of a complex brain. It plays an integra­ tive role in adaptation to the physical and social environments through reflexes, conditioning and more complex forms of learning. The brain is a repository for both inherited and acquired information. With the development of speech and the formation of symbolic language, the human brain has made it possible to transmit information cultur­ ally (horizontal) to other members of society, in addition to genetic (vertical) transmission to progeny. This horizontal transmission, which has reached its highest form in man, is a powerful extension of genetic transmission. The brain may provide man all that is of im­ portance in life. It has played a key role in the evolution of life by maintaining and extending the life span. Many mental or intellectual capacities of man reach a peak in early adulthood, remain relatively constant throughout maturity and then appear to decline during senescence. Behaviorally, there appears to be a decrease in sensory, learning and motor functions with aging in all mammalian species. As integrated adaptive control systems, the brain and neuroendocrines have been closely associated with the homeostatic adaptation to environmental challenges throughout .the life span.


biology brain information neurobiology

Editors and affiliations

  • J. Mark Ordy
    • 1
  • Kenneth R. Brizzee
    • 2
    • 3
  1. 1.Department of Neurobiology Delta Regional Primate Research CenterTulane UniversityCovingtonUSA
  2. 2.Division of Biomedical SciencesDelta Regional Primate Research CenterCovingtonUSA
  3. 3.Department of AnatomyTulane University School of MedicineNew OrleansUSA

Bibliographic information

  • DOI
  • Copyright Information Plenum Press, New York 1975
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-0927-7
  • Online ISBN 978-1-4684-0925-3
  • Series Print ISSN 0099-6246
  • Buy this book on publisher's site