Alternative Mechanisms of Multidrug Resistance in Cancer

  • John A. Kellen

Table of contents

  1. Front Matter
    Pages i-xii
  2. John A. Kellen
    Pages 1-30
  3. Henk J. Broxterman, Carolien H. M. Versantvoort
    Pages 67-80
  4. Dominic Fan, Diane R. Bielenberg, Yun-Fang Wang, Robert Radinsky, Pedro J. Beltran
    Pages 81-94
  5. Teruhiro Utsugi, Cynthia E. Herzog, Dominic Fan
    Pages 95-120
  6. Robert A. Newman, Dominic Fan
    Pages 153-171
  7. Catherine A. O’Brian, Nancy E. Ward, Krishna P. Gupta, Karen R. Gravitt
    Pages 173-190
  8. John C. Reed
    Pages 191-214
  9. Hironori Ishida, Hiroshi Kijima, Yukinori Ohta, Mohammed Kashani-Sabet, Kevin J. Scanlon
    Pages 225-264
  10. John A. Kellen
    Pages 265-273
  11. John A. Kellen
    Pages 275-278
  12. Back Matter
    Pages 279-281

About this book


Nullius in verba. . . Truth will be tested not by words. Horace (Epistles) Few read introductions except for book reviewers, who want to take a shortcut and avoid reading the book itself. However, tradition requires that the preface make public why the book was written at all (this is not supposed to include powerful reasons such as augmenting the ego of the editor and authors). Frequently, the inflationary tendency to publish in verbose length is in conflict with market forces and interest. No doubt, multidrug resistance is a "fashionable" topic, but there are many fashions displayed on the cat-walk of scientific literature. One can rationalize that the forces driving our concern with multi drug resistance reflect the frustration of pharmaceutical companies and oncologists alike: as soon as a new anticancer drug enters clinical trials, cancer cells start eluding extinction with their elaborate and successful mechanisms. Many grants have been awarded and spent, only to confirm the futility of our efforts to defeat this cellular Darwinism. Our medical and scientific training makes it hard, if not impossible, to accept that the survival of a malignant cell, alone or as part of a tissue, is part of the continuance of life. Since exposure to noxious and lethal substances is unavoidable, cells have been forced to develop a multitude of mechanisms to prevent entry or accelerate exit of such materials from intracellular space.


Cancer Drugresearch Pharmacology/Biology carcinoma chemoresistance

Editors and affiliations

  • John A. Kellen
    • 1
  1. 1.Sunnybrook Health Science CenterUniversity of TorontoTorontoCanada

Bibliographic information