Anticarcinogenesis and Radiation Protection

  • Peter A. Cerutti
  • Oddvar F. Nygaard
  • Michael G. Simic

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Free Radical Mechanisms

    1. Michael G. Simic, Edward P. L. Hunter, Slobodan V. Jovanovic
      Pages 17-24
    2. Mohammed Al-Sheikhly, Michael G. Simic
      Pages 47-50
  3. Oxygen Species in Carcinogenesis

    1. Walter Kozumbo, Dominique Muehlematter, Takafumi Ochi, Peter Cerutti
      Pages 51-57
    2. Bruce W. Steinert, Bonnie F. Sloane, David G. Menter, John D. Crissman, John D. Taylor, Kenneth V. Honn
      Pages 63-69
    3. William E. M. Lands, Robert B. Pendleton
      Pages 81-84
    4. Janardan K. Reddy, M. Sambasiva Rao
      Pages 85-91
    5. E. Schneider, J. J. Watson, R. A. Floyd
      Pages 93-96
    6. Thomas A. Dahl, Philip E. Hartman, W. Robert Midden
      Pages 109-113
  4. Enzymatic Repair of DNA Damage

    1. Leona Samson, Patrick Carroll, Bruce Derfler, William Rebeck
      Pages 121-127
    2. Yoke W. Kow, Hiroshi Ide, Susan S. Wallace
      Pages 135-138
    3. Robert J. Melamede, Yoke Wah Kow, Susan S. Wallace
      Pages 139-144
    4. Bruce Demple, Yasmin Daikh, Jean Greenberg, Arlen Johnson
      Pages 151-155
    5. Nathan A. Berger, Sosamma J. Berger, Donna C. Sudar
      Pages 163-167
  5. Tumor Promotion and Progression

    1. Stuart H. Yuspa, Henry Hennings, Takashi Sako, George R. Pettit, John Hartley, Peter M. Blumberg
      Pages 169-174
    2. Bonita G. Taffe, Thomas W. Kensler, Naohiro Takahashi, Ronald P. Mason
      Pages 191-197
    3. G. Witz, B. Czerniecki, S. C. Gad, Bernard D. Goldstein
      Pages 199-205
    4. J. B. Rotstein, J. F. O’Connell, T. J. Slaga
      Pages 211-219
    5. Norbert E. Fusenig, Petra Boukamp, Dirk Breitkreutz, Siegfried Karjetta, Rule T. Petrusevska
      Pages 227-231
  6. Chemoprevention

    1. Lee W. Wattenberg, J. Bradley Hochalter, Usha D. G. Prabhu, Arthur R. Galbraith
      Pages 233-240
    2. Carmia Borek, Augustinus Ong, Herbert Mason, Marco Zaider, Gisela Witz, Myron A. Mehlman
      Pages 247-252
    3. Johanna Lang, Kishorchandra Gohil, Laurie Rothfuss, Lester Packer
      Pages 253-257
    4. K. Fred Gey, Georg B. Brubacher, Hannes B. Stähelin
      Pages 259-267
    5. Charles H. Hennekens
      Pages 269-277
    6. G. S. Omenn, G. Goodman, L. Rosenstock, S. Barnhart, B. Lund, M. Thornquist et al.
      Pages 279-283
    7. Ann R. Kennedy, Paul C. Billings
      Pages 285-295
    8. Jonathan Yavelow, Judith H. Kraft, Lorraine Schepis
      Pages 297-301
    9. Amiya K. Ghoshal, T. H. Rushmore, D. Ghazarian, Amit Ghoshal, V. Subrahmanyan, E. Farber
      Pages 303-308
    10. S. C. Skoryna, P. Koch, E. Yeghiayan, M. Fuskova, A. Sauvé, J. F. Stara
      Pages 313-319
  7. Radiation Damage and Protection

    1. J. F. Ward, C. L. Limoli, P. Calabro-Jones, J. W. Evans
      Pages 321-327
    2. Eric J. Hall, Tom K. Hei, Gerhard Randers-Pehrson
      Pages 329-334

About this book


This book is based on the invited and contributed papers presented at the 2nd International Conference on Anticarcinogenesis and Radiation Protection held at the National Bureau of Standards, Gaithersburg, Maryland, USA, on March 8-12, 1987. The conference documented developments that have taken place in areas that were addressed during the first conference in 1982. A number of new topics, such as biological response modifiers, were included because of their emerging relevance to anticarcinogenesis and radiation protection. The organization of the material in this book does not follow the conference program; rather, we have attempted to provide a different sequence for didactic reasons. The aim of the conference, which is reflected in this book, was to promote further development of mechanistic approaches to cancer prevention and treatment based on recent progress in molecular biology and free radical chemistry. At the basis of carcinogenesis lie changes in the dynamics of growth and differentiation of specific cell subpopulations in the target tissue. 'These changes are brought about by selective toxicity and modulation of gene expression that are induced by xenobiotic carcinogens and affected by physiological and genetic factors. The book deals with oxidative stress and molecular damage caused by radiation and chemical pro-oxidants and their role in carcinogenesis, and it discusses mechanisms of deregulation of the expression of oncogenes and other genes involved in carcinogenic initiation and promotion.


cancer prevention carcinogenesis cell molecular biology prevention radiation protection

Editors and affiliations

  • Peter A. Cerutti
    • 1
  • Oddvar F. Nygaard
    • 2
  • Michael G. Simic
    • 3
  1. 1.Swiss Institute for Experimental Cancer ResearchLausanneSwitzerland
  2. 2.Case Western Reserve UniversityClevelandUSA
  3. 3.National Bureau of StandardsGaithersburgUSA

Bibliographic information