Advances in Swine in Biomedical Research

Volume 2

  • Mike E. Tumbleson
  • Lawrence B. Schook

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Methods and Techniques

    1. Michael P. Murtaugh, Nancy A. Monteiro-Riviere, Linda Panepinto
      Pages 423-424
    2. Nancy A. Monteiro-Riviere, Jim Riviere
      Pages 425-458
    3. William G. Reifenrath, Barbara W. Kemppainen, Winifred G. Palmer
      Pages 459-474
    4. Vyacheslav E. Ryabinin
      Pages 475-483
    5. Harold W. Gonyou
      Pages 485-490
    6. Hiroaki Funahashi, Billy N. Day
      Pages 491-502
    7. Brett R. White, JoElla Barnes, Matthew B. Wheeler
      Pages 503-521
    8. Guy F. Bouchard, Ronald M. McLaughlin, Mark R. Ellersieck, Gary F. Krause, Craig Franklin, Chada S. Reddy
      Pages 533-542
    9. George J. Ikeda, Theodore C. Michel, Dennis W. Gaines, Vira L. Olivito, Philip P. Sapienza, Leonard Friedman et al.
      Pages 543-555
    10. Leonard Friedman, Linda Panepinto, Dennis W. Gaines, Ruey Chi, Robert C. Braunberg, James Terris
      Pages 557-570
    11. Sam J. Bhathena, Elliott Berlin, Wesley A. Johnson
      Pages 571-579
    12. Elliott Berlin, Melanie A. Banks, Sam J. Bhathena, Renee C. Peters, Wesley A. Johnson
      Pages 581-593
    13. Robert N. Willette, Hong Zhang, Calvert Louden, Robert K. Jackson
      Pages 595-606
    14. David K. Johnson, Erik R. Wisner, Stephen M. Griffey, Adele R. Vessey, Patrick J. Haley
      Pages 607-612
    15. M. Michael Swindle, Robert P. Thompson, Alison C. Smith, George B. Keech, Blase A. Carabello, Wolfgang Radtke et al.
      Pages 613-620
    16. H. Vince Mendenhall, Christopher Horvath, Marek Piechowiak, Lisa Johnson, Kim Bayer
      Pages 621-627
    17. Donald B. Wiest, M. Michael Swindle, Sandra S. Garner, Alison C. Smith, Paul C. Gillette
      Pages 629-635
    18. Stan W. Casteel, Ross P. Cowart, Christopher P. Weis, Gerry M. Henningsen, Eva Hoffman, William J. Brattin et al.
      Pages 637-646

About this book


Similarities in structure and function between pigs and human beings include size, feeding patterns, digestive physiology, dietary habits, kidney structure and function, pulmo­ nary vascular bed structure, coronary artery distribution, propensity to obesity, respiratory rates, tidal volumes and social behaviors. Since the pig is an omnivore, it provides an adaptable model to evaluate chronic and acute exposures to xenobiotics such as alcohoL caffeine, tobacco, food additives and environmental pollutants. Swine have been used successfully as models to evaluate alcoholism, diabetes, absorption, digestion, total paren­ teral nutrition, organ transplantation, atherosclerosis, exercise, hypertension. hemorrhagic hypotension, melanoma, gingivitis, obstructive and reflux nephropathy. osteochondrosis. dermal healing and septic shock. A severe and worsening shortage of organs and tissues for transplantation in patients with severe organ failure has encouraged the consideration of inter species or xenotransplan­ tation. In developing programs toward this end, the pig generally is viewed as the preferred donor because of its size, physiology and availability. The pig harbors relatively few diseases which could be transmitted inadvertently to human patients. The ability to genetically modify swine to ameliorate the consequences of the human immune response offers a further significant advantage. Another important consideration for an animal model is that basic biologic back­ ground information be available for investigators to design future prospective studies.


Absorption Amino acid additives alcohol diabetes metabolism nutrition physiology tissue transplantation transport xenobiotics

Editors and affiliations

  • Mike E. Tumbleson
    • 1
  • Lawrence B. Schook
    • 2
  1. 1.University of IllinoisUrbanaUSA
  2. 2.University of MinnesotaSt. PaulUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1996
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7699-6
  • Online ISBN 978-1-4615-5885-9
  • About this book