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Gene Therapy of Cancer

  • Peter Walden
  • Uwe Trefzer
  • Wolfram Sterry
  • Farzin Farzaneh
  • Patricia Zambon
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 451)

Table of contents

  1. Front Matter
    Pages i-xvi
    PDF

  2. Tumor Biology

    1. Expression Genetics in Cancer Research, Prognosis, and Therapy
      Katherine J. Martin, R. Sager
      Pages 1-7
    2. Patterns of Chromosomal Imbalances in Carcinomas of the Respiratory Tract
      Iver Petersen, Ulrike Bockmühl, Simone Petersen, Günter Wolf, Manfred Dietel
      Pages 9-16
    3. Inhibition of Tumorigenesis in a Murine B-Cell Lymphoma Transplant Model By c-Myc Complementary Oligonucleotides
      Janet B. Smith, Eric Wickstrom
      Pages 17-22
    4. Telomerase Inhibition by Induced Expression of Antisense RNA
      Antje Müller, G. Saretzki, T. von Zglinicki
      Pages 23-26
    5. Ex Vivo and In Vivo IGF-I Antisense RNA Strategies for Treatment of Cancer in Humans
      D. D. Anthony, Y. X. Pan, S. G. Wu, F. Shen, Y. J. Guo
      Pages 27-34
    6. Use of the IGF-I Antisense Strategy in the Treatment of the Hepatocarcinoma
      Lia C. Upegui-Gonzalez, Huynh T. Duc, Yves Buisson, Michel Arborio, Christiane Lafarge-Frayssinet, Claude Jasmin et al.
      Pages 35-42
    7. Functional Involvement of CD44, a Family of Cell Adhesion Molecules, in Immune Responses, Tumour Progression and Haematopoiesis
      Ursula Günthert, C. Schwärzler, B. Wittig, J. Laman, P. Ruiz, R. Stauder et al.
      Pages 43-49
    8. The Influence of CD44 Splice Variants to the Outcome of Patients with Oral Squamous Cell Carcinoma
      Christian Stoll, G. Baretton, F. Soost, U. Löhrs
      Pages 51-55
    9. Control of Tumor Growth Via Inhibition of Tumor Angiogenesis
      Karl H. Plate
      Pages 57-61
    10. Expression of Collagenase-3 (MMP-13) by Tumor Cells in Squamous Cell Carcinomas of the Head and Neck
      Veli-Matti Kähäri, N. Johansson, R. Grénman, K. Airola, U. Saarialho-Kere
      Pages 63-68
    11. High Level Expression of Tissue Inhibitors of Metalloproteinases-1,-2 and -3 in Melanoma Cells Achieved by Adenovirus Mediated Gene Transfer
      M. Ahonen, A. H. Baker, Veli-Matti Kähäri
      Pages 69-72
    12. Tissue Inhibitor of Metalloproteinase Expression
      A. M. McElligott, A. H. Baker, H. McGlynn
      Pages 73-77
    13. In Vivo Tumor Suppressor Effect of Retrovirus-Mediated Gene Transfer of the Adenovirus E1a Gene
      R. Sanchez-Prieto, M. Quintanilla, A. Cano, M. Lleonart, P. Martin, Santiago Ramon y Cajal
      Pages 79-86
    14. Antitumor Effect of E1B Defective Adenoviruses in Human Malignant Cells
      P. Martín Duque, C. Alonso, R. Sánchez-Prieto, M. Lleonart, Santiago Ramón y Cajal
      Pages 87-89
    15. Inhibition of Human Pancreatic Cancer Growth by the Adenovirus-Mediated Introduction of a Novel Growth Suppressing Gene, tob, In Vitro
      Hironobu Yanagie, H. Sumimoto, Y. Nonaka, S. Matsuda, I. Hirose, S. Hanada et al.
      Pages 91-96

  3. Chemogene Therapy

    1. Intratumoral Injection of Encapsulated Cells Producing an Oxazaphosphorine Activating Cytochrome P450 for Targeted Chemotherapy
      Peter Karle, Petra Müller, Renate Renz, Ralf Jesnowski, Robert Saller, Kerstin von Rombs et al.
      Pages 97-106
    2. Sensitisation of Human Ovarian Cancer Cells to Killing by the Prodrug CB1954 Following Retroviral or Adenoviral Transfer of the E. coli Nitroreductase Gene
      Peter F. Searle, S. J. Weedon, I. A. McNeish, M. G. Gilligan, M. J. Ford, F. Friedlos et al.
      Pages 107-113
    3. HSV-1 Thymidine Kinase Gene Therapy for Peritoneal Carcinomatosis
      C. Lechanteur, F. Princen, S. Lo Bue, B. Detroz, G. Fillet, J. Gielen et al.
      Pages 115-119
    4. Characteristics of Cytosine Deaminase-5-Fluorocytosine System
      Jaroslaw Szary, E. Missol, S. Szala
      Pages 121-123
    5. Potentiation of the Bystander Effect by Immunization Combined With Suicide Gene Therapy
      Rajagopal Ramesh, Aizen J. Marrogi, Anupama Munshi, Scott M. Freeman
      Pages 125-131
    6. Another Mechanism Causing the Bystander Effect Besides the GAP Junction’s Role During the Glioma Gene Therapy With HSV-TK/GCV System
      Liping Du, Shaochun Bai, Ian R. Whittle, Lin He
      Pages 133-138
    7. In Vivo Evaluation of a Drug-Inducible Vector System for the Combined Gene-and Chemotherapy of Cancer
      Wolfgang Walther, U. Stein, I. Fichtner, H. Naundorf, M. Alexander, R. H. Shoemaker et al.
      Pages 139-144
    8. IL-2 Gene Transfer for Chemosensitization of Multidrug-Resistant Human Colon Carcinoma Cells
      Ulrike Stein, Wolfgang Walther, Robert H. Shoemaker, Peter M. Schlag
      Pages 145-149
    9. Cytotoxic Effect of Binar Cisplatin Immunoconjugate
      V. M. Plotnikov
      Pages 151-152
    10. Dietary Indole Derivatives Induce Apoptosis in Human Breast Cancer Cells
      Fuad A. Fares, Xiaokang Ge, Shmuel Yannai, Gad Rennert
      Pages 153-157

  4. Tumor Immunology

    1. Overcoming T Cell Ignorance by Providing Costimulation
      Lieping Chen
      Pages 159-165
    2. Immune Cells in the Tumor Microenvironment
      Theresa L. Whiteside
      Pages 167-171
    3. Dendritic Cells Prevent CD95 Mediated T Lymphocyte Death through Costimulatory Signals
      Peter T. Daniel, C. Scholz, J. Westermann, B. Dörken, A. Pezzutto
      Pages 173-177
    4. Interleukin-10 Inhibits the Immune Stimulatory Potential of Melanoma Cells Retrovirally Transduced with Human B7.1 or B7.2
      Ralf Geertsen, F.-Y. Yue, J. Pavlovic, E. Laine, R. Dummer
      Pages 179-188
    5. Immunosuppressive Cells in Bone Marrow of Patients with Stomach Cancer
      Sergei A. Kusmartsev, I. N. Kusmartseva, S. G. Afanasyev, N. V. Cherdyntseva
      Pages 189-194
    6. Induction of Antigen-Specific T Cells by Allogeneic CD80 Transfected Human Carcinoma Cells
      G. C. Meyer, U. Moebius, W. Rudy, R. Batrla, S. C. Meuer, D. Wallwiener et al.
      Pages 195-202
    7. IL-12-Activated NK Cells Recognize B7 Costimulatory Molecules on Tumor Cells and Autologous Dendritic Cells
      Anja B. Geldhof, M. Moser, P. De Baetselier
      Pages 203-210
    8. Effects of Altered Antigen Processing on T-Cell Responses Toward Murine T-Lymphomas
      Geert Raes, J. Van Ginderachter, N. Devoogdt, A. Geldhof, P. De Baetselier
      Pages 211-215
    9. Cancer Gene Therapy with a Heat Shock Protein Gene
      O. E. Pardo, J. M. Colston, Katalin V. Lukacs
      Pages 217-223
    10. Heat Shock Protein (HSP72) Surface Expression Enhances the Lysis of a Human Renal Cell Carcinoma by IL-2 Stimulated NK Cells
      Jan Roigas, E. S. Wallen, S. A. Loening, P. L. Moseley
      Pages 225-229
    11. Identification of Epitopes for CTCL-Specific Cytotoxic T Lymphocytes
      Thomas Linnemann, Carsten Brock, Katrin Sparbier, Marcus Muche, Arlett Mielke, Ansgar Lukowsky et al.
      Pages 231-235
    12. Effects of Altered Antigen Processing on H-2Dk Mediated NK Inhibition in a Murine T Lymphoma Model
      J. Van Ginderachter, G. Raes, N. Devoogdt, P. De Baetselier, A. Geldhof
      Pages 237-240
    13. Recognition of Melanoma-Associated Peptides by Peripheral Blood Mononuclear Cells of Ocular Melanoma Patients
      J. Saba, C. A. McIntyre, R. C. Rees, A. K. Murray
      Pages 241-244
    14. Detection of Micrometastasis in 31 Patients with Breast Cancer by RT-PCR and Immunomagnetic Separation (ISM) Techniques
      Ramiro Cevallos, M. Del Pozo, D. Zylberait, P. Naepels, P. Veyssier, L. Geffray et al.
      Pages 245-246

  5. Immunogene Therapy

    1. Human Tumor Immunotherapy
      Jean-Charles Cerottini, D. Valmori, D. Rimoldi, P. Romero
      Pages 247-250
    2. Modification of Cancer Vaccines by Virus Infection and Attachment of Bispecific Antibodies
      Volker Schirrmacher, Claudia Haas
      Pages 251-257
    3. Immunotherapy of Established Tumor with MHC Class II and B7.1 Cell-Based Tumor Vaccines
      Suzanne Ostrand-Rosenberg, Beth A. Pulaski, Todd D. Armstrong, Virginia K. Clements
      Pages 259-264
    4. Retroviral B7.1 Gene Transfer in Cancer Cells Protects Cytotoxic T Cells from Deletion by “Veto” Apoptosis
      Peter T. Daniel, Arne Kroidl, Sophie Cayeux, Christian Scholz, Isrid Sturm, Thomas Blankenstein et al.
      Pages 265-276
    5. Hybrid Cell Vaccination in Cancer Immunotherapy
      G. Stuhler, U. Trefzer, P. Walden
      Pages 277-282
    6. Treatment of Hepatocellular Carcinoma with the Cellular Tumor Vaccines Generated by in Vitro Modification of Tumor Cells with Non Gene Transfer Approaches
      Shuguang Wu, Jing Ma, Xiaoyan Che, Yanjun Liu, Hao Wang, Jian Zhao et al.
      Pages 283-293
    7. DNA Vaccines Targeting Dendritic Cells for the Immunotherapy of Cancer
      T. Tüting, C. C. Wilson, D. M. Martin, J. Baar, A. DeLeo, M. T. Lotze et al.
      Pages 295-304
    8. A DNA Vaccine against Malignant Melanoma Coexpressing Antigen and Cytokine
      M. Nawrath, J. Heinrich, B. Strack, J. Pavlovic, Karin Moelling
      Pages 305-310
    9. DNA Immunization in Mice against Virus-Induced Tumor Antigens
      Gabriella Milan, Antonio Rosato, Annalisa Zambon, Paola Zanovello, Dino Collavo
      Pages 311-314
    10. IL-4 Gene Transfer for the Treatment of Experimental Gliomas
      S. Benedetti, F. Di Meco, N. Cirenei, M. G. Bruzzone, B. Pollo, N. Florio et al.
      Pages 315-321

About this book

Introduction

The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.

Keywords

Herpes simplex Peptide angiogenesis apoptosis bone carcinoma endothelium tissue tumor growth tumorigenesis

Editors and affiliations

  • Peter Walden
    • 1
  • Uwe Trefzer
    • 1
  • Wolfram Sterry
    • 1
  • Farzin Farzaneh
    • 2
  • Patricia Zambon
    • 1
  1. 1.Humboldt UniversityBerlinGermany
  2. 2.King’s College School of Medicine and DentistryLondonUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-5357-1
  • Copyright Information Plenum Press, New York 1998
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7444-2
  • Online ISBN 978-1-4615-5357-1
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site