Clinical Applications of Cytokines and Growth Factors

  • John R. Wingard
  • George D. Demetri

Part of the Developments in Oncology book series (DION, volume 80)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Biology of Hematopoietic and Lymphopoietic Cytokines

    1. Front Matter
      Pages 1-1
    2. Grover C. Bagby Jr., Michael C. Heinrich
      Pages 2-55
    3. Paul J. Simmons, David N. Haylock, Jean-Pierre Levesque, Andrew C. W. Zannettino
      Pages 56-73
    4. Richard A. Carter, Edmund K. Waller
      Pages 74-89
  3. Management of Neutropenia and Neutropenic Fever

    1. Front Matter
      Pages 117-117
    2. J. Milton Gaviria, W. Conrad Liles, David C. Dale
      Pages 118-136
    3. Edward B Rubenstein, Linda S. Elting, Charlotte C. Sun, Kenneth V. I. Rolston
      Pages 159-177
    4. David B. Jendiroba, Benjamin Lichtiger, Emil J. Freireich
      Pages 178-185
  4. Management of Anemia

  5. Management of Thrombocytopenia

    1. Front Matter
      Pages 217-217
    2. Ronald Hoffman, Michael W. Long
      Pages 218-236
    3. Ravi Vij, John DiPersio
      Pages 237-268
    4. Russell L. Basser
      Pages 269-277
  6. The Role of Cytokines to Enhance Cancer Chemotherapy

    1. Front Matter
      Pages 278-278
    2. Henrik van Deventer, Thomas Shea
      Pages 279-299
    3. Richard M. Stone
      Pages 313-324
  7. Management of Marrow Failure States

  8. The Use of Cytokines in Blood and Marrow Transplantation

  9. Back Matter
    Pages 403-407

About this book


The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off of invading microbes by humoral, cell-mediated, and phagocytic immunity. The activity of the hematopoietic system is staggering: daily, a normal adult produces approximately 2.5 billion erythrocytes, 2.5 billion platelets, and 1 billion granulocytes per kilogram of body weight. This production is adjusted in a timely fashion to changes in actual needs and can vary from nearly none to many times the normal rate depending on needs which vary from day to day, or even minute to minute. In response to a variety of stimuli, the cellular components of the blood are promptly increased or decreased in production to maintain appropriate numbers to optimally protect the host from hypoxia, infection, and hemorrhage. How does this all happen and happen without over or under responding? There has been extraordinary growth in our understanding ofhematopoiesis over the last two decades. Occupying center stage is the pluripotent stern cell and its progeny. Hematopoietic stern cells have been characterized by their capacity for self renewal and their ability to proliferate and differentiate along multiple lineages. Few in number, the stern cell gives rise to all circulating neutrophils, erythrocytes, lymphoid cells, and platelets. In hematopoietic transplantation, the stern cell is capable of restoring long-term hematopoiesis in a lethally irradiated host.


anemia blood chemotherapy cytokine cytokines growth growth factor transplantation

Editors and affiliations

  • John R. Wingard
    • 1
  • George D. Demetri
    • 2
  1. 1.Bone Marrow Transplant Program, Division of Hematology/OncologyUniversity of Florida College of Medicine, Shands HospitalGainesvilleUSA
  2. 2.Department of Adult OncologyDana-Farber Cancer Institute and Harvard Medical SchoolBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1999
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7277-6
  • Online ISBN 978-1-4615-5013-6
  • Buy this book on publisher's site