Mouse Models in the Study of Genetic Neurological Disorders

  • Brian Popko

Part of the Advances in Neurochemistry book series (ANCH, volume 9)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Domna Karagogeos, Ourania Pavlou
    Pages 63-97
  3. William D. Snider, Inmaculada Silos-Santiago
    Pages 99-118
  4. Carmen Lampron, Sébastien Couillard-Després, Jean-Pierre Julien
    Pages 119-135
  5. Toni L. Williamson, W. Don Cleveland
    Pages 137-162
  6. David R. Borchelt, Philip C. Wong, Sangram S. Sisodia, Donald L. Price
    Pages 187-214
  7. Donald E. Schmechel, Pu-Ting Xu, John R. Gilbert, Allen D. Roses
    Pages 215-243
  8. Kunihiko Suzuki, Marie T. Vanier, Kinuko Suzuki
    Pages 245-283
  9. Muriel T. Davisson, Alberto C. S. Costa
    Pages 297-327
  10. Thomas N. Seyfried, Michael Poderycki, Mariana Todorova
    Pages 329-359
  11. Back Matter
    Pages 361-366

About this book


The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly. Therefore, it was difficult to select the models that were reviewed in this volume. Clearly, there are important models that are not discussed, and perhaps a volume twice this size would have been more appropriate. Moreover, the pace at which new models are being developed and analyzed is rapid. As this volume goes to press, I am sure that additional mouse genes responsible for naturally occurring neurological disorders are being discovered and that many new transgenic and mutant mouse strains are being developed. Therefore, this volume should not be viewed as a comprehensive compendium, but rather as an update of work in progress. It is exhilarating to witness the fast pace at which these models are being established as important tools in the study of basic neuroscience and neurological disorders. It will be even more exciting to see their utilization in the development and testing of therapeutic interventions for these diseases. I would like to thank each of the authors who have contributed to this volume for their time and their expertise. I would also like to thank Drs. Timothy Coetzee and Joshua Corbin for their advice in the selection of the topics covered. I am deeply indebted to Dr. Kunihiko Suzuki, who first approached me with the idea for this volume, for his guidance throughout its preparation.


Allele Alzheimer ELIZA genetics neuroscience

Editors and affiliations

  • Brian Popko
    • 1
  1. 1.University of North Carolina at Chapel HillChapel HillUSA

Bibliographic information