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Advances in DNA Damage and Repair

Oxygen Radical Effects, Cellular Protection, and Biological Consequences

  • Miral Dizdaroglu
  • Ali Esat Karakaya

Part of the NATO ASI Series book series (NSSA, volume 302)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Steven Akman, Regen Drouin, Gerald Holmquist, Henry Rodriguez
    Pages 1-17
  3. Vilhelm A. Bohr, Adabalayam Balajee, Robert Brosh, Jan Nehlin, Amrita Machwe, Michele Evans et al.
    Pages 27-34
  4. Serge Boiteux, J. Pablo Radicella
    Pages 35-45
  5. J. Cadet, M. Bardet, M. Berger, T. Berthod, T. Delatour, C. D’Ham et al.
    Pages 47-58
  6. Bruce Demple, Elisabeth Bailey, Richard A. O. Bennett, Yuji Masuda, Donny Wong, Yong-jie Xu
    Pages 59-66
  7. Paul W. Doetsch, Anand Viswanathan, Wei Zhou, Jiang Liu
    Pages 97-110
  8. Errol C. Friedberg, William J. Feaver, Wenya Huang, Michael S. Reagan, Simon H. Reed, Zhaoyang You et al.
    Pages 111-123
  9. Matthew B. Grisham, David Jourd’heuil, David A. Wink
    Pages 125-134
  10. Lawrence Grossman, Genevieve Matanoski, Evan Farmer, Mohammad Hedyati, Sugita Ray, Bruce Trock et al.
    Pages 149-167
  11. Philip C. Hanawalt, Graciela Spivak
    Pages 169-179
  12. Ali E. Karakaya, Semra Sardas, Sema Burgaz
    Pages 181-191
  13. Kazimierz S. Kasprzak, Wojciech Bal, Dale W. Porter, Karol Bialkowski
    Pages 193-208
  14. Hans E. Krokan, Frank Skorpen, Marit Otterlei, Sangeeta Bharati, Kristin Steinsbekk, Hilde Nilsen et al.
    Pages 221-236
  15. Jacques Laval, Cécile Bauche, Juan Jurado, Franck Paillard, Murat Saparbaev, Olga Sidorkina
    Pages 237-250
  16. Stuart Linn
    Pages 259-266
  17. Steffen Loft, Henrik Enghusen Poulsen
    Pages 267-281
  18. J. Lunec, I. D. Podmore, H. R. Griffiths, K. E. Herbert, N. Mistry, P. Mistry
    Pages 283-294
  19. Sankar Mitra, Tadahide Izumi, Istvan Boldogh, Chilakamarti V. Ramana, Ching-Chyuan Hsieh, Hiroshi Saito et al.
    Pages 295-311
  20. Hiroshi Ohshima, Vladimir Yermilov, Yumiko Yoshie, Julieta Rubio
    Pages 329-339
  21. Nancy L. Oleinick, Song-mao Chiu, Liang-yan Xue, Karl J. Mann
    Pages 341-351
  22. Mehmet Öztürk, Kezban Unsal
    Pages 371-376
  23. Joyce T. Reardon, Aziz Sancar
    Pages 377-393
  24. Clemens von Sonntag
    Pages 407-418
  25. Susan S. Wallace, Lynn Harrison, Dongyan Jiang, Jeffrey O. Blaisdell, Andrei A. Purmal, Zafer Hatahet
    Pages 419-430
  26. John F. Ward
    Pages 431-439
  27. Back Matter
    Pages 441-511

About this book

Introduction

Damage to DNA by both exogenous and endogenous sources is increasingly regarded as highly important in the initiation and progression of cancer and in the occurance of other pathological events. DNA damage caused by reactive oxygen-derived species, also called oxidative DNA damage, is most the frequent type encountered by aerobic cells. Mechanistic studies of carcinogenesis indicate an important role of this type of damage to DNA. There is also strong evidence to support the role of oxidative DNA damage in the aging process. DNA damage is opposed in vivo by repair systems. If not repaired, DNA damage may lead to detrimental biological consequences. Therefore, the repair of DNA damage is regarded as one of the essential events in all life forms. In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. A detailed knowledge of mechanisms of DNA damage and repair, and how individual repair enzymes function may lead to manipulation of DNA repair in cells and ultimately to an increase of the resistence of human cells to DNA-damaging agents. This volume covers the most recent devlopments in this research field and contains contributions from scientists working in the fields of biochemistry, molecular biology, enzymology, biomedical science, and radiation biology.

Keywords

Base DNA Nucleotide RNA biochemistry enzymes molecular biology saccharomyces cerevisiae transcription

Editors and affiliations

  • Miral Dizdaroglu
    • 1
  • Ali Esat Karakaya
    • 2
  1. 1.National Institute of Standards and TechnologyGaithersburgUSA
  2. 2.Gazi UniversityAnkaraTurkey

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-4865-2
  • Copyright Information Kluwer Academic / Plenum Publishers, New York 1999
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7207-3
  • Online ISBN 978-1-4615-4865-2
  • Buy this book on publisher's site