Perspectives on Biologically Based Cancer Risk Assessment

  • Vincent James Cogliano
  • E. Georg Luebeck
  • Giovanni A. Zapponi

Part of the Nato · Challenges of Modern Society book series (NATS, volume 23)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. V. J. Cogliano, E. D. Kroese, G. A. Zapponi, L. Attias, I. Marcello
    Pages 1-20
  3. V. J. Cogliano, A. Kappas, G. Voutsinas, G. A. Zapponi
    Pages 21-47
  4. A. Kappas, V. J. Cogliano, K. Watanabe, G. A. Zapponi
    Pages 49-80
  5. V. J. Cogliano, E. G. Luebeck, G. A. Zapponi
    Pages 183-204
  6. E. G. Luebeck, K. Watanabe, C. Travis
    Pages 205-241
  7. E. G. Luebeck, C. Travis, K. Watanabe
    Pages 275-308
  8. J. J. Amaral-Mendes, J. V. Cogliano, A. Kappas, C. Kitsos, E. D. Kroese, E. G. Luebeck et al.
    Pages 309-314
  9. Back Matter
    Pages 315-319

About this book


The first meeting of the NATO/CCMS Pilot Study "Dose-Response Analysis and Biologically-Based Risk assessment for Initiator and Promoter Carcinogens" was held in Rome, Italy, in the spring of 1991, and was followed by annual or bi-annual meetings held in Germany, Greece, Netherlands, Portugal, USA, up to the end of 1995; in large part supported by NATO/CCMS grants or fellowships, and organized by Pilot Study participants. The Pilot Study activity has been characterized by a higly collaborative atmosphere, which was essential for a deep and detailed analysis of a problem on which different points of view, methodological approaches and regulations exist in the various member countries. The Pilot Study was aimed at proposing a carcinogenic risk assessment procedure which is based on a detailed analysis of the relevant biological processes, and may also consent the verification of hypotheses. The specific form of theoretical and mathe­ matical models is identified by considering and using the whole set of objective data available. The multidisciplinary approach of the pilot study is reflected by the struc­ ture of this book. Each chapter is the result of the cooperation of several authors from to produce a comprehensive manual that includes different countries; its objective was both theoretical and practical information.


DNA apoptosis cancer carcinogenesis carcinoma cell development kinetics liver mutagen mutagenesis oncogene research toxicity tumor

Editors and affiliations

  • Vincent James Cogliano
    • 1
  • E. Georg Luebeck
    • 2
  • Giovanni A. Zapponi
    • 3
  1. 1.United States Environmental Protection AgencyUSA
  2. 2.Fred Hutchinson Cancer Research CenterSeattleUSA
  3. 3.National Institute of HealthRomeItaly

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic/Plenum Publishers 1999
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7149-6
  • Online ISBN 978-1-4615-4741-9
  • Buy this book on publisher's site