Principles of Cardiovascular Neural Regulation in Health and Disease

  • Alberto Malliani

Part of the Basic Science for the Cardiologist book series (BASC, volume 6)

Table of contents

About this book


This book is an attempt to indicate to researchers and clinicians a simple way to approach the complexity of cardiovascular neural regulation. A conceptual pillar like homeostasis is contrasted with instability and a continuous interaction of opposing mechanisms that have negative and positive feedback characteristics, and is considered to subserve the multitude of patterns pertaining to physiology. However, in pathophysiological conditions the final design is most often replaced by largely purposeless neural mechanisms.
The complexity of cardiovascular neural regulation, reflected by the state of sympathovagal balance, is also assessed in the frequency domain. Power spectrum analysis of heart rate and arterial pressure variability, a sophisticated but simply explained approach, provides an unprecedented tool to evaluate this interaction in both physiological and pathophysiological conditions. The elementary characteristics of nonlinear dynamics are also outlined. Finally, the need for an ethical structure for science and medicine is analyzed.


arterial pressure cardiovascular heart heart rate neural mechanisms physiology

Authors and affiliations

  • Alberto Malliani
    • 1
    • 2
    • 3
  1. 1.Centro Ricerche Cardiovascolari, CNRUniversità di MilanoItaly
  2. 2.Dipartimento Scienze Precliniche LITA-VialbaUniversità di MilanoItaly
  3. 3.Dipartimento di Medicina Interna, Ospedale “L. Sacco”Università di MilanoItaly

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2000
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6971-4
  • Online ISBN 978-1-4615-4383-1
  • Series Print ISSN 1566-0753
  • Buy this book on publisher's site