Advertisement

Skin Langerhans (Dendritic) Cells in Virus Infections and AIDS

  • Yechiel Becker

Part of the Developments in Medical Virology book series (DIMV, volume 7)

Table of contents

  1. Front Matter
    Pages i-xv
  2. General

    1. Front Matter
      Pages 1-1
    2. M. Kashihara-Sawami, S. Imamura
      Pages 39-58
    3. Eli Sprecher, Leonard D. Shultz, Yechiel Becker
      Pages 59-76
  3. Cancer and Aging

    1. Front Matter
      Pages 77-77
    2. H. Konrad Muller, Gary M Halliday
      Pages 79-97
    3. Eli Sprecher, Leonard D. Shultz, Yechiel Becker
      Pages 99-118
  4. HIV Infection of Langerhans Cells in AIDS

    1. Front Matter
      Pages 119-119
    2. Peter Oxholm, Annemette Oxholm, Henrik Permin, Klaus Bendtzen
      Pages 121-130
    3. L.R. Braathen, C. Mørk
      Pages 131-139
    4. Steven Patterson, Steven Macatonia, Jacqueline Gross, Penelope Bedford, Stella Knight
      Pages 141-156
  5. Herpes Simplex Virus-1 Infection of the Skin and Langerhans Cells

    1. Front Matter
      Pages 183-183
    2. N. A. Williams, W. A. Blyth, T. J. Hill
      Pages 185-201
    3. Tomoko Otani-Tanahashi, Ryoichi Mori
      Pages 203-220
    4. Sarah E.M. Howie, James A. Ross
      Pages 221-239
  6. Human Warts and Langerhans Cells

    1. Front Matter
      Pages 261-261
    2. Y. Chardonnet, J. Viac
      Pages 263-278
  7. Pox and Iridovirus Interactions with Skin Langerhans Cells

    1. Front Matter
      Pages 279-279
    2. Dan David, Hagai Yadin, Eli Sprecher, Mertyn Malkinson, Yechiel Becker
      Pages 285-288
    3. Douglas A. Gregg, Douglas S. Soroka, Charles A. Mebus
      Pages 289-297
  8. Perspectives

    1. Front Matter
      Pages 299-299
    2. Yechiel Becker
      Pages 301-305
  9. Back Matter
    Pages 307-320

About this book

Introduction

Over the generations the skin has been the site for immunization against smallpox. This method of immunization was described in a letter written by Lady Mary Montagu on April 1, 1717 in Adrianopole, Turkey: "The small-pox, so fatal, and so general amongst us, is here entirely harmless by the invention of ingrafting, which is the term they give it. . . The old woman comes with a nut-shell full of the matter of the best sort of small-pox . . . She immediately rips open (the skin) with a large needle . . . and puts into the vein as much venom as can lie upon the head of her needle, and after binds up the wound. There is no example of anyone that died of it; and you may believe that I am satisfied of the safety of this experiment since I intend to try it on my dear little son" (Letters from the right Honourable Lady Mary Montagu 1709-1762. Published by J. M. Dent and Co. London, 2nd edition, September, 1906, p. 124. ) The "variolation" method was, 80 years later, markedly improved by the use of cowpox virus, as reported by Edward Jenner in 1796. The successful method of intradermal immunization against smallpox and later against other virus diseases is in fact based on the presence of anitigen-presenting dendritic cells in the skin.

Keywords

AIDS HIV Herpes simplex aging antibody blood cancer cell dendritic cells diseases infection infections skin disease vaccination virus

Editors and affiliations

  • Yechiel Becker
    • 1
  1. 1.Hebrew UniversityJerusalemIsrael

Bibliographic information