Childhood Leukemia: Present Problems and Future Prospects

Proceedings of the Second International Symposium on Children’s Cancer Tokyo, Japan, December 7–9, 1989

  • Noboru Kobayashi
  • Tai Akera
  • Shuki Mizutani

Part of the Developments in Oncology book series (DION, volume 65)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Biology of Childhood Leukemia

    1. Front Matter
      Pages 1-1
    2. Melvyn F. Greaves, Li Chong Chan, Anthony M. Ford, Susan M. Pegram, Leanne M. Wiedemann
      Pages 3-22
    3. Makio Ogawa, Kenji Kishi, Jing Ping Shih
      Pages 23-31
    4. Kenichi Harigaya
      Pages 33-41
    5. John C. Reed, Michael P. Cuddy, Subrata Haldar, Carlo Croce, Peter Nowell, David Makover et al.
      Pages 43-50
    6. Yasuhide Hayashi, Susana C. Raimondi, A. Thomas Look
      Pages 59-68
    7. Junichiro Fujimoto, Nobutaka Kiyokawa, Hiroo Fujita, Kazumi Imai, Yoshie Matsubayashi, Yasuo Kokai et al.
      Pages 69-76
    8. Shuki Mizutani, Kozue Nakamura, Toshiyuki Miyashita, Miwako Ozaki, Kouichi Miyamura’, Takao Matsuei’ et al.
      Pages 77-86
    9. Keisei Kawa-Ha, Akio Tawa, Keiko Yumura-Yagi, Junichi Hara, Shigehiko Ishihara
      Pages 87-93
  3. Epidemiology of Childhood Leukemia

  4. Treatment of Childhood Leukemia

    1. Front Matter
      Pages 127-127
    2. Joseph V. Simone, Gaston K. Rivera, A. Thomas Look, William M. Crist
      Pages 129-134
    3. W. Archie Bleyer, David G. Poplack, Frank M. Balis
      Pages 149-155
    4. Shinpei Nakazawa, Akitoshi Kinoshita, Masahiro Tsuchida, Ryota Hosoya, Kozo Nishmura, Masao Yamamoto et al.
      Pages 167-177
    5. Robert Peter Gale, Anna Butturini, Mortimer M. Bortin
      Pages 179-183
    6. Shunichi Kato, Miharu Yabe, Hiromasa Yabe, Chidori Kubota, Rumi Mitsuda, Yasumasa Oh et al.
      Pages 185-193
    7. Mutsuro Ohira, Jun Takayama
      Pages 195-201
    8. Jun-ichi Akatsuka, Takuo Hirotsu, Yasutaka Hoshi, Keiko Kamiya, Yoko Kato, Hiroshi Uchiyama et al.
      Pages 213-222
  5. The Total Care and the Patient Support System for Children with Leukemia

About this book


Twenty years ago when Children's Cancer Association of Japan was born, the diagnosis of childhood leukemia amounted to a death sentence. Only 20% or so of children with leukemia survived more than 5 years. Since then, enormous improvements have been achieved regarding our understanding on the etiology, diagnosis, and the treatment of childhood leukemia. Now, 70% of children with leukemia survive and enter adult life. Even though the improved survival rate of children with leukemia represents a medical success story, we now face new problems. The first problem is the fact that we still lose 20-30% of patients with childhood leukemia. To address this problem, we need to understand the etiology, epidemiology, and biology of leukemia; to identify the patients at greater risk; and to develop adequate treatments. The second problem is the treatment itself. Even though efficacious, the modem treatment for leukemia is a grueling experience for children and their families. We should develop a total care system for families and children based on a deep understanding of their needs. The third problem is the aftereffects of the treatment and of cured leukemia. Extensive radiation and chemotherapy have an entirely different spectrum of long-term effects on children than on adults. These treatments in the early stage of life, when the mind and body are developing, create many physical and psychological problems. These are the present problems of childhood leukemia.


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Editors and affiliations

  • Noboru Kobayashi
    • 1
  • Tai Akera
    • 2
  • Shuki Mizutani
    • 3
  1. 1.National Children’s HospitalSetagaya-ku, Tokyo 154Japan
  2. 2.The National Children’s Hospital Medical Research CenterTokyoJapan
  3. 3.Department of VirologyThe National Children’s Medical Research CenterSetagaya-ku, Tokyo 154Japan

Bibliographic information