Chemical Carcinogenesis 2

Modulating Factors

  • Amedeo Columbano
  • Francesco Feo
  • Rosa Pascale
  • Paolo Pani

Table of contents

  1. Front Matter
    Pages i-xii
  2. Oncogenes and Cancer Development

    1. Front Matter
      Pages 1-1
    2. P. Sassone-Corsi, S. J. Busch, F. Schlotter, J. Auwerx, B. Mellström, N. S. Foulkes et al.
      Pages 3-9
    3. A. Carcereri De Prati, M. Menegazzi, G. M. Ledda Columbano, A. Columbano, M. Miwa, H. Suzuki
      Pages 19-27
    4. P. Coni, G. Pichiri-Coni, G. M. Ledda-Columbano, P. M. Rao, S. Rajalakshmi, D. S. R. Sarma et al.
      Pages 29-38
    5. M. M. Simile, M. A. Seddaiu, M. E. Ruggiu, G. Vannini, G. Satta, M. J. Sequenza et al.
      Pages 39-47
    6. H. C. Pitot, M. J. Neveu, J. H. Hully, L. Sargent, D. Paul, B. Nicholson
      Pages 49-64
    7. R. Pascale, M. M. Simile, M. E. Ruggiu, L. Daino, G. Satta, M. A. Seddaiu et al.
      Pages 65-86
    8. V. Préat, Y. Nizet, S. Haesen, M. Roberfroid
      Pages 111-118
    9. A. Buchmann, J. Mahr, R. Bauer-Hofmann, M. Schwarz
      Pages 119-121
  3. Genetic Factors

    1. Front Matter
      Pages 137-137
    2. M. E. Kazanecki, T. J. Gill III
      Pages 145-157
    3. P. L. Cocco, S. Dessi, P. Manca, R. Cherchi, M. Pisano, P. F. Todde
      Pages 159-164
    4. T. A. Dragani, G. Manenti, B. M. Colombo, G. Della Porta
      Pages 165-176
    5. M. F. Melhem, A. L. Cortese-Hassett, M. Kazaneki, K. N. Rao, H. W. Kunz, T. J. Gill III
      Pages 177-186
  4. Metabolic Regulation in Cancer Development

    1. Front Matter
      Pages 187-187
    2. P. Bannasch, F. Klimek, D. Mayer, H. J. Hacker, T. Dettler, H. Zerban
      Pages 189-202
    3. B. Batetta, S. Dessì, D. Pulisci, O. Spano, E. Laconi, P. Pani
      Pages 251-256
    4. A. Ito, N. Fujimoto, B. Roy, K. Inoue
      Pages 257-264
    5. J. Doyle, B. Kabakoff, A. A. Kandutsch
      Pages 289-297
    6. S. Dessì, B. Batetta, D. Pulisci, P. Accogli, C. Anchisi, L. Tessitore et al.
      Pages 311-320
    7. M. E. Kazanecki, M. F. Melhem, K. N. Rao, R. H. Kelly, H. W. Kunz, T. J. Gill III
      Pages 321-326
    8. G. Barrera, F. Biasi, V. M. Fazio, L. Paradisi, M. U. Dianzani
      Pages 337-342
    9. G. Muzio, R. A. Canuto, M. E. Biocca, M. U. Dianzani
      Pages 343-348
    10. M. A. Rossi, F. Fidale, A. Garramone, M. U. Dianzani
      Pages 349-356
    11. A. Blanck, L. C. Eriksson, Y. Assefaw-Redda, D. Svensson, I. Porsch-Hällström
      Pages 357-365
    12. C. Di Ilio, A. Aceto, T. Bucciarelli, A. Columbano, G. M. Ledda-Columbano, G. Federici
      Pages 367-372
    13. S. Grilli, S. Bartoli, B. Bonora, A. Colacci, G. Lattanzi, M. Mazzullo et al.
      Pages 381-391
    14. R. Vellosi, E. Morichetti, R. Del Carratore, D. Rosellini, G. Cantelli-Forti, M. Paolini et al.
      Pages 393-402
    15. D. Kanduc, M. R. Rossiello, A. M. C. Aresta, T. Ranieri, D. Calò, E. Quagliariello
      Pages 403-407
    16. C. Isidoro, A. Mesiti, G. Bonelli, L. Tessitore, A. Hasilik, F. M. Baccino
      Pages 409-418
  5. Cell Death and Multistage Chemical Carcinogenesis

    1. Front Matter
      Pages 419-419
    2. V. N. Afanasyev, B. A. Korol, I. I. Kruman, N. P. Matylevich, V. A. Pechatnikov, S. R. Umansky
      Pages 421-431
    3. J. S. Amenta, M. J. Sargus, G. Bonelli, F. M. Baccino
      Pages 433-442
    4. L. Tessitore, P. Costelli, C. Sacchi, F. M. Baccino
      Pages 443-449
    5. R. A. Lockshin, Z. F. Zakeri, L. M. Yesner
      Pages 451-459

About this book


"chemical carcinogenesis" is the general title of the series of international meetings which are held, biannually, in sardinia (Italy) since 1981. Despite the generality of the title, the main effort of the scientific Committee has been to pursue a coherent line around one of the most distinguishing features of carcinogenesis: the "multifasic" development of the process. Given that many chemical compounds are known to cause "experimental cancer", many questions still remain unresolved or are given too simplistic answers. The very first question concerning the interaction between the chemical carcinogen and the molecular target in the cell is a debatable one despite the overwhelming literature in this field. It is certain that chemical carcinogens are toxic to cells and cause DNA damage: however it is still an open question as to how to relate these changes to the different stages of carcinogenesis including initiation. We have not to forget that 1/3 to 2/3 of the average life time of a given species elapses between the experimental administration of the carcinogen and the appearance of "cancer". The experimental manipulation of carcinogenesis through the use of "adequate biological models" has not simplified the problems about cancer, but it has led us to face the complexity of otherwise elementary biological properties, cell proliferation and differentiation. The understanding of this biological complexity is not just theoretical, but it may give us those adequate conceptual tools to approach "cancer" also from a medical point of view.


DNA apoptosis breast cancer cancer carcinogenesis cell cell death hormones liver prevention tumor

Editors and affiliations

  • Amedeo Columbano
    • 1
  • Francesco Feo
    • 2
  • Rosa Pascale
    • 2
  • Paolo Pani
    • 1
  1. 1.University of CagliariCagliariItaly
  2. 2.University of SassariSassariItaly

Bibliographic information