Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies

1. Experience of the EORTC Radiotherapy/Chemotherapy Group in osteosarcoma trials

   • J. M. V. Burgers

   Pages 173-175

2. Intraoperative radiation therapy for osteosarcoma

   • Takao Yamamuro, Yoshihiko Kotoura

   Pages 177-183

3. Surgery of Osteosarcoma of the extremities: Indications and complications in the recent Experience at the Istituto Ortopedico Rizzoli

   • P. Ruggieri, R. Biagini, G. Bacci, A. Ferraro, A. Ferruzzi, R. De Cristofaro et al.

   Pages 185-203

4. Limb sparing for skeletally immature patients with osteosarcoma: The expandable prosthesis

   • Samuel Kenan, Daniel P. DeSimone, Michael M. Lewis

   Pages 205-211

5. A modular endoprosthetic system, noninvasively extendable, for young patients with osteosarcoma

   • Bart Verkerke, Heimen Schraffordt Koops, René P. H. Veth, Liedeke Postma, Henk J. Grootenboer

   Pages 213-220

6. A critique of techniques for reconstruction after internal hemipelvectomy for osteosarcoma

   • R. P. H. Veth, H. Schraffordt Koops, H. K. L. Nielsen, J. Oldhoff, G. J. Verkerke, A. Postma

   Pages 221-229

7. Diffusion of methotrexate from surgical acrylic cement

   • P. Hernigou, B. Brun, A. Astier, D. Goutallier, J. P. le Bourgeois

   Pages 231-233

8. Hyperthermic isolated perfusion using cisplatin for treatment of the extremities

   • Shinsei Takeyama, Akio Tateishi, Shozoh Higaki, Masayuki Yamanashi

   Pages 235-240

9. Hyperthermic isolation limb perfusion (HILP) in the management of extremity melanoma and sarcoma with particular reference to the dosage, pharmacokinetics, and toxicity of cisplatin

   • William S. Fletcher, Eugene A. Woltering, H. Stephens Moseley, Gary Bos, Luis Lebredo, David Brown et al.

   Pages 241-244

10. Effect of isolated limb perfusion with cisplatin (CDDP) on canine osteosarcoma

    • H. J. Hoekstra, F. J. Meutstege, J. W. Oosterhuis, J. De Vries, H. Schraffordt Koops

    Pages 245-249

11. Salvage surgery for childhood osteosarcoma

    • Ugo Pastorino, Marco Gasparini, Alberto Azzarelli, Luca Tavecchio, Gianni Ravasi

    Pages 251-260

12. The multi-institutional osteosarcoma study: An update

    • Michael P. Link

    Pages 261-267

13. Treatment of osteosarcoma: Experience of the Cooperative Osteosarcoma Study Group (COSS)

    • Kurt Winkler, Stefan S. Bielack, Günter Delling, Herbert Jürgens, Rainer Kotz, Mechthild Salzer-Kuntschik

    Pages 269-277

14. The European Osteosarcoma Intergroup (E.O.I.) studies 1980–1991

    • A. W. Craft, J. M. V. Burgers

    Pages 279-286

15. The Childrens Cancer Group (CCG) Studies

    • James S. Miser, Mark Krailo

    Pages 287-291

16. An update of Scandinavian studies of osteosarcoma

    • Inkeri Elomaa

    Pages 293-298

17. Neoadjuvant chemotherapy for nonmetastatic osteosarcoma of the extremities: The recent experience at the Rizzoli Institute

    • G. Bacci, P. Picci, S. Ferrari, M. Avella, Brach A. del Prever, P. Ruggieri et al.

    Pages 299-308

18. Osteosarcoma of the extremities: Chemotherapy experience at Memorial Sloan-Kettering

    • Paul A. Meyers, Glenn Heller, Vaia Vlamis

    Pages 309-322

19. Osteosarcoma studies at St. Jude Children’s Research Hospital from 1968 through 1990

    • C. B. Pratt, W. H. Meyer, B. N. Rao, D. M. Parham, I. D. Fleming

    Pages 323-326

20. A monocentric therapy study: An approach to optimize the results of the treatment of osteosarcoma by protocols based upon HDMTX, associated with systematic conservative surgery

    • N. Delepine, G. Delepine, J. C. Desbois

    Pages 327-332

Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies is the fifth volume in the series `Cancer Treatment, and Research' devoted to pediatric oncology. Like its immediate predecessor, Hodgkin's Disease in Children: Controversies and Current Practice, this volume also deals with the current state of affairs: where do researchers differ in opinions or firmly held beliefs? What does the future hold for research or for the patients who have benefited from research and are now cured? etc.
The first part deals with preclinical and clinical issues that relate to the disease and the second part deals with the results of recent trials and in some cases ongoing trials. It could be argued that section B Pharmacology, Section D Radiotherapy and Section E Surgery of part one belong to part two; however in these sections we have tried to focus on one discipline and in part two, we have tried to focus on the results of multidisciplinary trials. A third part includes a few critiques and editorial comments.
This volume was prepared and planned for both basic and clinical oncologists. It is hoped that the basic scientists will gain some insight into the problems of their clinical colleagues and that the clinicians will be willing to read to the more basic articles. It is not a text for students (or for that matter physicians) who want all things to be laid out in `black and white'. But it is a text for those students who want to know how vibrant this field of research is and are willing to stand in awe of how much research needs to be done.

• cancer treatment
• pathology
• pharmacology
• radiotherapy
• surgery

• Medical College of Ohio at Toledo, USA

  G. Bennett Humphrey

• University of Groningen, Netherlands

  H. Schraffordt Koops, W. M. Molenaar, A. Postma

Policies and ethics