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Cerebellar Degenerations: Clinical Neurobiology

  • Andreas Plaitakis

Part of the Foundations of Neurology book series (FONY, volume 2)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Introduction: The Cerebellum and its Disorders in the Dawn of the Molecular Age

  3. Basic Neurosciences of the Cerebellum

  4. Clinical Neurosciences of the Cerebellum

    1. Front Matter
      Pages 183-183
    2. Arnulf H. Koeppen, David I. Turok
      Pages 205-236
    3. H.-C. Diener, J. Dichgans
      Pages 261-280
    4. M. Fetter, J. Dichgans
      Pages 281-304
    5. Andreas Plaitakis, Shoichi Katoh, Yun Peng Huang
      Pages 305-365
  5. Etiopathogenesis of Cerebellar Disorders

    1. Front Matter
      Pages 367-367
    2. Andreas Plaitakis, P. Shashidharan
      Pages 369-390
    3. Sandro Sorbi, John P. Blass
      Pages 391-401
    4. Martha A. Nance, Lawrence J. Schut
      Pages 425-441
    5. Massimo Fiorilli, Maurizio Carbonari, Michela Cherchi, Carlo Gaetano
      Pages 461-474
    6. J. E. Hammack, J. B. Posner
      Pages 475-497
  6. Back Matter
    Pages 499-507

About this book

Introduction

This book encompasses basic and clinical reports on the cerebellum and its primary atrophic disorders, the cerebellar degenerations. Rapid progress has been made in undestanding the organization and function of the cerebellum at the neuronal, synaptic, and molecular level. Of particular importance has been the identification of the chemical transmitters utilized by the cer­ ebellar cellular systems. More than any other brain region, the cerebellum utilizes amino acids as its main excitatory and inhibitory neurotransmitters. Excitatory amino acid transmitters, in addition to serving neuronal com­ munication, may also mediate trophic and toxic effects, and as such, they may playa role in neurodegenerative processes. The cerebellar degenerations were among the first human disorders with primary system atrophy to be studied clinically and pathologically. This field of clinical cerebellar sciences, no longer confined to the previously known descriptive level, is now advancing rapidly, propelled by rapid advances in neuroimaging, immunology, and molecular biology. The advent of CT, MRI, and PET has in recent years permitted the study of central nervous system alterations in living patients, thus contributing substantially to the accuracy of the diagnosis and the classification of these disorders. The nosology of cerebellar degenerations, which has been the subject of much debate for over a century, is presently a dynamic field, with new entities being recognized and old "classic ataxias" being redefined in the light of new genetic evidence.

Keywords

anatomy cortex neurobiology neurophysiology neuroscience physiology

Editors and affiliations

  • Andreas Plaitakis
    • 1
  1. 1.Department of NeurologyMount Sinai School of MedicineNew YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-3510-2
  • Copyright Information Springer-Verlag US 1992
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6557-0
  • Online ISBN 978-1-4615-3510-2
  • Series Print ISSN 0924-8935
  • Buy this book on publisher's site