Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development

Proceedings of the Twenty-Second Annual Cancer Symposium Detroit, Michigan, USA — April 26–28, 1990

  • Frederick A. Valeriote
  • Thomas H. Corbett
  • Laurence H. Baker

Part of the Developments in Oncology book series (DION, volume 68)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Frederick Valeriote, Thomas Corbett, Laurence Baker
    Pages 1-9
  3. Thomas H. Corbett, Frederick A. Valeriote, Lisa Polin, Chiab Panchapor, Susan Pugh, Kathryn White et al.
    Pages 35-87
  4. A. J. Barker, L. R. Hughes, P. Warner, K. Burrows, A. L. Jackman
    Pages 89-103
  5. Wendell Wierenga
    Pages 105-122
  6. Paul H. Fischer, Eric R. Larson, Robert L. Dow, Penny E. Miller
    Pages 149-157
  7. W. R. Leopold, Judith S. Sebolt-Leopold
    Pages 179-196
  8. Paul F. Cavanaugh Jr., Kenneth C. Mattes
    Pages 197-204
  9. Frederick H. Hausheer, U. Chandra Singh, Jeffrey D. Saxe, Alexander L. Weis
    Pages 215-224
  10. David S. Alberts, Denise J. Roe, Patricia M. Plezia, John G. Kuhn, Lisa E. Davis
    Pages 237-245
  11. Shih-Fong Chen, Daniel L. Dexter
    Pages 261-280
  12. John R. Murphy, Diane P. Williams, Tetsuyuki Kiyokawa, Paige L. Anderson, Terry B. Strom
    Pages 281-301
  13. Carl W. Porter, Debora L. Kramer, Ralph J. Bernacki, Raymond J. Bergeron
    Pages 325-344
  14. Terrence W. Doyle, Jerzy Golik, Henry Wong, Kin Sing Lam, David Langley, Salvatore Forenza et al.
    Pages 345-358
  15. K. S. Smith, G. J. Badiner, E. G. Adams, D. K. Wilson, L. H. Li, B. K. Bhuyan
    Pages 359-378
  16. Norwood R. Anderson, Jacob J. Lokich
    Pages 379-401

About this book


The focus of the 22nd Annual Detroit Cancer Symposium was the presentation and discussion of cytotoxic agents, with a significant portion of the symposium including the exciting frontiers of drug discovery being explored by the National Cooperative Drug Discovery Groups (NCDDG) Program. The symposium brought together a large number of investigators from government, universities and pharmaceutical companies involved in the discovery and development of new anticancer agents. Exciting new leads were presented and the status of others presently under development was discussed.
Of particular significance has been the initiation of renewed efforts in the area of natural product drug discovery, where the discovery of new cytotoxics is very promising at the moment. A number of major changes have occurred during the last decade in research on drug discovery of cytotoxic agents. Critical reviews of a number of the models and concepts underlying drug discovery represented a continuous thread throughout the meeting, being constantly discussed in terms of their advantages, disadvantages and capabilities of discovering solid tumor active anticancer agents.
A recent development which is to be much applauded and which portends to great discoveries is the new relationship formed between Government, University of Industry. The NCDDG mechanism which stimulates this interaction is an inexpensive manner to greatly magnify the drug discovery and development effort nationally. Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development represents a forum which will become the major mode for bringing together these three different components in the equation to regularly discuss new results and ideas.


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Editors and affiliations

  • Frederick A. Valeriote
    • 1
  • Thomas H. Corbett
    • 1
  • Laurence H. Baker
    • 1
  1. 1.Wayne State University School of MedicineDetroitUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1992
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6548-8
  • Online ISBN 978-1-4615-3492-1
  • Buy this book on publisher's site