Natural Products as Antiviral Agents

  • Chung K. Chu
  • Horace G. Cutler

Table of contents

  1. Front Matter
    Pages i-viii
  2. Mohamed Nasr, James Cradock, Margaret Johnston
    Pages 31-56
  3. Kirk R. Gustafson, John H. Cardellina II, Kirk P. Manfredi, John A. Beutler, James B. McMahon, Michael R. Boyd
    Pages 57-67
  4. Kuo-Hsiung Lee, Yoshiki Kashiwada, Gen-ichiro Nonaka, Itsuo Nishioka, Makoto Nishizawa, Takashi Yamagishi et al.
    Pages 69-90
  5. Daniel Meruelo, Steven Degar, Nuria Amari, Yehuda Mazur, David Lavie, Brandi Levin et al.
    Pages 91-119
  6. Bjarne Gabrielsen, Thomas P. Monath, John W. Huggins, Jorma J. Kirsi, Melinda Hollingshead, William M. Shannon et al.
    Pages 121-135
  7. Gary S. Jacob, Peter Scudder, Terry D. Butters, Ian Jones, David C. Tiemeier
    Pages 137-152
  8. Sylvia Lee-Huang, Hao-Chia Chen, Hsiang-fu Kung, Philip L. Huang, Peter L. Nara, Bao-Qun Li et al.
    Pages 153-170
  9. M. S. McGrath, K. C. Luk, H. D. Abrams, I. Gaston, S. Santulli, S. E. Caldwell et al.
    Pages 171-193
  10. Ghee T. Tan, John M. Pezzuto, A. Douglas Kinghorn
    Pages 195-222
  11. Daniel Lednicer, Ven L. Narayanan
    Pages 223-238
  12. Masahiro Tada, Kazuhiro Chiba, Takao Yoshii
    Pages 239-255
  13. Back Matter
    Pages 275-279

About this book

Introduction

During the past fifty years, thousands of natural products have been isolated from plants, fungi, and bacteria. Apart from intense searches by pharmaceutical companies for medicinals and the concentrated effort mounted by the National Cancer Institute, many of these have not been tested in biological systems. The major reasons for this appear to be, at least, twofold. First, individual researchers looking for biologically active natural products will often isolate only small amounts of material sufficient to determine a structure and calculate the specific activity for their particular bioassay systems: insufficient funds preclude re-isolating the compound unless industrial potential is foreseen. Second, the difficulty with which original structures were proved prior to 1972. This required the isolation of relatively large quantities of a natural product and there followed extensive degradation, elemental analyses of the parent and its fragments, then synthesis, piece by piece, of the molecule. All this took time and energy. No wonder that when the structure was proved the chemist was enervated. And coupled to this was the fact that many chemists were not trained to test their materials in biological systems. In contrast, today a natural product can be isolated, its mass and molecular formula determined and, if there is some serendipity, crystals may be obtained for single crystal x-ray analysis. If conditions are near perfect, it is possible to isolate and identify a novel compound in a month.

Keywords

Amaryllidaceae HIV bacteria cancer development fungi immunodeficiency infection infections natural products plant plants proteins research virus

Editors and affiliations

  • Chung K. Chu
    • 1
  • Horace G. Cutler
    • 2
  1. 1.The University of GeorgiaAthensUSA
  2. 2.Agricultural Research ServiceUnited States Department of AgricultureAthensUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-3414-3
  • Copyright Information Plenum Press, New York 1992
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6509-9
  • Online ISBN 978-1-4615-3414-3
  • About this book