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Oncogene and Transgenics Correlates of Cancer Risk Assessments

  • Constantine Zervos

Part of the NATO ASI Series book series (NSSA, volume 232)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Elizabeth L. Anderson
    Pages 1-20
  3. Suresh H. Moolgavkar
    Pages 21-29
  4. Kevin R. O’Driscoll, Scott M. Kahn, Christoph M. Borner, Wei Jiang, I. Bernard Weinstein
    Pages 43-59
  5. Demetrios A. Spandidos, Margaret L. M. Anderson
    Pages 61-66
  6. Tommaso A. Dragani, Giacomo Manenti, Manuela Gariboldi, F. Stefania Falvella, Marco A. Pierotti, Giuseppe Della Porta
    Pages 67-80
  7. Monique Castagna, Jacqueline Robert Lezenes, Xupei Huang, Nicole Hanania
    Pages 81-90
  8. J. S. Rhim, J. H. Yang, I. H. Lee, M. S. Lee, J. B. Park
    Pages 91-109
  9. David M. Ornitz, Radek Skoda, Randall W. Moreadith, Philip Leder
    Pages 155-172
  10. Armand Tavitian
    Pages 173-184
  11. Chang-Ho Ahn, Won-Chul Choi
    Pages 185-197
  12. Helga Spieker-Polet, Periannan Sethupathi, Herman Polet, Pi-Chen Yam, Katherine L. Knight
    Pages 199-216
  13. Rory B. Conolly, Kannan Krishnan, Melvin E. Andersen
    Pages 217-229
  14. Sandro Grilli, Silvio Parodi, Maurizio Taningher, Annamaria Colacci
    Pages 263-291
  15. Silvio Parodi, Davide Malacarne, Sandro Grilli, Annamaria Colacci, Maurizio Taningher
    Pages 293-303
  16. Bruce Molholt
    Pages 305-311
  17. Back Matter
    Pages 333-351

About this book

Introduction

The data, the information, and even the overarching knowledge necessary for risk assessments of economically important environmental carcinogens come, for the most part, from the applied biological disciplines, e. g. , toxicology, epidemiology, biostatistics, etc. The more fundamental biological disciplines, e. g. , biochemistry, cell biology, molecular biology, molecular genetics of cancer, etc. , have enormous but unrealized potential to improve current cancer risk assessment methods. The objective of this advanced research workshop ARW was to advance the state of the art of cancer risk assessment methods by identifying potential short and long term contributions to such methods from the more fundamental disciplines. Attention was paid to short and long term contributions from research advances in the biochemistry and physiology of oncogenes (oncogenes research) and in the construction and utilization of transgenic animals (transgenics research). In the last 20 years, researchers in the fundamental biological disciplines, i. e. , biochemists, geneticists, molecular and cell biologists, etc. , have, inter alia, advanced spectacularly our understanding of the nature of neoplastic diseases. Their phenomenal progress is the combined result of both advances and refinements of the techniques available to them and of new fundamental discoveries. Among the latter the most significant are the discoveries of oncogenes and of the feasibility of creating transgenic animals, i. e. , of transferring well defined and expressible genes from the cells of one species of organisms to the embryonic cells of another.

Keywords

Embryo biochemistry genes genetics molecular biology physiology transgenic animals

Editors and affiliations

  • Constantine Zervos
    • 1
  1. 1.Consulting in Health and Environmental ProtectionSimpsonvilleUSA

Bibliographic information