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Advances in Neutron Capture Therapy

  • Albert H. Soloway
  • Rolf F. Barth
  • David E. Carpenter

Table of contents

  1. Front Matter
    Pages i-xxx
  2. Baiba V. Harrington, Geoffrey Constantine
    Pages 15-20
  3. M Carolan, G Constantine, R Godfrey, H Meriaty, G Storr, B J Allen
    Pages 21-24
  4. J. Burian, M. Marek, J Rataj, V. Mares, P. Stopka, O. Strouf
    Pages 25-28
  5. Yoshinori Sakurai, Tooru Kobayashi, Koichi Ono, Takashi Sato, Keiji Kanda
    Pages 33-36
  6. T. Vilaithong, W. Hoffmann, G. Hoyes, S. Dangtip, S. Singkarat, P. Suanpoot
    Pages 43-46
  7. Gregory J. Storr, Baiba V. Harrington
    Pages 47-51
  8. Bartlomiej Ciesielski, Lucian Wielopolski
    Pages 53-57
  9. P. Watkins, Y. Harker, C. Amaro, W. Voorbraak, F. Stecher-Rasmussen, H. Verhagen et al.
    Pages 59-65
  10. David W. Nigg, Gregory J. Storr, Floyd J. Wheeler
    Pages 71-74
  11. Hungyuan B. Liu, Robert M. Brugger, David C. Rorer
    Pages 75-79
  12. Iiro Auterinen, Pekka Hiismäki
    Pages 81-84
  13. J. C. Yanch, R. E. Shefer, B. J. Hughey, R. E. Klinkowstein
    Pages 95-98
  14. T. E. Blue, T-X B. Qu, N. Gupta, R. A. Gahbauer
    Pages 99-103
  15. Terry H. Wu, Robert M. Brugger, Jay F. Kunze
    Pages 105-108
  16. Tanxia Qu, Thomas E. Blue, Kevin Herminghuysen, Christos Kanellitsas, Reinhard Gahbauer
    Pages 115-118
  17. C-K C. Wang, P. E. Eggers, H. L. Crawford
    Pages 119-123
  18. J. K. Kim, J. C. Yanch, M. J. Wilson
    Pages 131-134
  19. Yosh Maruyama, Jacek Wierzbicki, Jose M. Feola
    Pages 135-137
  20. J. Wierzbicki, C. Alexander, Y. Maruyama
    Pages 139-141
  21. Guy P. Estes, William M. Taylor
    Pages 147-151
  22. Gregory J. Storr, Floyd J. Wheeler
    Pages 153-157
  23. M. W. Konijnenberg, L. G. H. Dewit, B. J. Mijnheer, C. P. J. Raaijmakers, F. Stecher-Rasmussen, P. R. D. Watkins
    Pages 159-163
  24. Hungyuan B. Liu, Robert M. Brugger
    Pages 165-169
  25. Lawrence E. Reinstein, Eric B. Ramsay, Janusz Gajewski, Sundaresan Ramamoorthy, Allen G. Meek
    Pages 171-175
  26. John Niemkiewicz, Thomas E. Blue
    Pages 177-180
  27. J. Gajewski, E. B. Ramsay, L. E. Reinstein
    Pages 185-189
  28. M. K. Marashi, A. Pazirandeh
    Pages 191-195
  29. Guido R. Solares, Robert G. Zamenhof, Guillermo Cano
    Pages 213-216
  30. Robert M. Brugger, Hungyuan B. Liu, Brenda H. Laster, Christopher R. Gordon, Dennis D. Greenberg, Lynne S. Warkentien
    Pages 225-229
  31. Jerzy T. Masiakowski, John L. Horton, Lester J. Peters
    Pages 231-234
  32. Yasuyuki Akine, Nobuhiko Tokita, Koichi Tokuuye, Michinao Satoh, Minako Sumi, Yoshinobu Fukumori et al.
    Pages 241-243
  33. Koichi Tokuuye, Nobuhiko Tokita, Yasuyuki Akine, Tooru Kobayashi, Keiji Kanda
    Pages 245-248

About this book

Introduction

Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non­ ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.

Keywords

Amino acid Nucleoside Nucleotide Tumor reaction

Editors and affiliations

  • Albert H. Soloway
    • 1
  • Rolf F. Barth
    • 1
  • David E. Carpenter
    • 1
  1. 1.The Ohio State UniversityColumbusUSA

Bibliographic information