Anticancer Drug Resistance

Advances in Molecular and Clinical Research

  • Lori J. Goldstein
  • Robert F. Ozols

Part of the Cancer Treatment and Research book series (CTAR, volume 73)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. June L. Biedler, Barbara A. Spengler
    Pages 1-16
  3. Ellen Buschman, Pierre Lepage, Philippe Gros
    Pages 17-39
  4. Catherine A. O’Brian, Nancy E. Ward, Karen R. Gravitt, Dominic Fan
    Pages 41-55
  5. Snorri S. Thorgeirsson, Timothy W. Gant, Jeffrey A. Silverman
    Pages 57-68
  6. Lee M. Greenberger, Dalia Cohen, Susan Band Horwitz
    Pages 69-106
  7. Michael M. Gottesman, Gerald H. Mickisch, Ira Pastan
    Pages 107-128
  8. Cynthia E. Herzog, Susan E. Bates
    Pages 129-147
  9. Branimir I. Sikic, George A. Fisher, Bert L. Lum, Nathalie A. Brophy, Anne M. Yahanda, Kent M. Adler et al.
    Pages 149-165
  10. Patricia V. Schoenlein
    Pages 167-200
  11. Paul A. Andrews
    Pages 217-248
  12. O. Michael Colvin
    Pages 249-262
  13. Allan Y. Chen, Leroy F. Liu
    Pages 263-281
  14. Back Matter
    Pages 283-294

About this book


Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 500,000 cancer-related deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation.
Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance, the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated.
Although MDR is currently the most understood mechanism of drug resistance, we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance.
It is clear that drug resistance is complex, and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy.


cancer cancer therapy clinical research clinical trial cytotoxicity diagnosis diseases drug drug resistance gene therapy genetics leukemia research resistance toxicity

Editors and affiliations

  • Lori J. Goldstein
    • 1
  • Robert F. Ozols
    • 1
  1. 1.Fox Chase Cancer CenterPhiladelphiaUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 1994
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6129-9
  • Online ISBN 978-1-4615-2632-2
  • Series Print ISSN 0927-3042
  • Buy this book on publisher's site