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Immunology of Human Papillomaviruses

  • Book
  • © 1994

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Editors:
  1. Margaret A. Stanley

    1. Department of Pathology, University of Cambridge, Cambridge, UK

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Table of contents (49 chapters)

  1. Humoral Responses to HPV

    1. IgG Antibodies to Human Papillomavirus Type 16 and Serum Retinol May Jointly Protect Against Cervical Neoplasia

      • M. Lehtinen, J. Dillner, A. Aromaa, R-K. Aaran, T. Hakulinen, P. Knekt et al.
      Pages 113-118

    2. Prognostic Significance of Antibodies to HPV-16 E7 /E4 Proteins and Fragments of Cytokeratin 19 in Invasive Cervical Carcinoma

      • K. N. Gaarenstroom, J. M. G. Bonfrer, G. G. Kenter, C. M. Korse, Th. J. M. Heimerhorst, J. B. Trimbos
      Pages 119-123

    3. Development of Serological Assays for Detection of ANTI-HPV-16 E6 and E7 Antibodies

      • Anna K. Ghosh, Simon N. Stacey, Leticia Rocha Zavaleta, Nigel K. Smith, John R. Arrand, Peter L. Stern
      Pages 125-132

    4. Detection by Elisa Test of Antibodies to Human Papillomavirus (HPV) Type 16 E7 Oncoprotein in Patients with Benign or Malignant Papillomas from Skin or Mucosa

      • Y. Chardonnet, A. Janiaud, J. J. Chomel, J. Viac, S. Euvrard, D. Schmitt et al.
      Pages 133-138

    5. Seroreactivity to a L2-Derived Synthetic Peptide Correlates with the Number of Surgery-Necessitating Recurrences in Patients with Laryngeal Papillomatosis

      • Ruth Tachezy, Eva Hamsikova, Jaroslav Valvoda, Jan Betka, Robert D. Burk, Vladimir Vonka et al.
      Pages 139-145

    6. Comparison of PV Conformational Epitopes Expressed by L1 Proteins in Mammalian (COS) and Insect (SF9) Cells

      • Shin-je Ghim, Richard Schlegel, Jeffrey F. Hines, Neil D. Christensen, John Kreider, A. Bennett Jenson
      Pages 147-153

    7. Detection of Class-Specific Antibodies to Baculovirus-Derived Human Papillomavirus Type 16 (HPV-16) Capsid Proteins

      • John Cason, Parminder K. Kambo, Bhavneet Shergill, John Bible, Barbara Kell, Richard J. Jewers et al.
      Pages 155-160

  2. Cell Mediated Immunity to HPV

    1. Evolution of Class I HLA Antigen Presenting Molecules

      • Peter Parham
      Pages 161-172

    2. Major Histocompatibility Complex (MHC) Expression and Antigen Presentation in Cervical Cancer

      • Jennifer S. Bartholomew, Simon N. Stacey, Brian Coles, Margaret Duggan-Keen, Philip A. Dyer, Susan S. Glew et al.
      Pages 173-179

    3. Analysis of MHC Class I Expression in HPV 16 Positive Cervical Carcinomas, in Relation to C-MYC Overexpression

      • F. V. Cromme, P. J. F. Snijders, A. J. C. van den Brule, M. J. Stukart, P. Kenemans, C. J. L. M. Meijer et al.
      Pages 181-188

    4. Immunogenetic Study of Women with HPV Related Cancer of the Uterine Cervix

      • Patrizia Tenti, Miryam Martinetti, Solange Romagnoli, Enrico Silini, Cinzia Pizzochero, Rita Zappatore et al.
      Pages 189-193

    5. Recurrent Respiratory Papillomatosis (RRP): Enriched HLA DQw3 Phenotype and Decreased Class I MHC Expression

      • Vincent R. Bonagura, Mary Ellen O’Reilly, Allan L. Abramson, Bettie M. Steinberg
      Pages 195-200

    6. HPV 16-Derived Synthetic Peptides with Ability to Upregulate MHC Class I Expression on RMA-S or T2 Cells, as Detected by Enzyme Immunoassay

      • Joakim Dillner
      Pages 201-205

    7. Regulation of MHC Class I, Class II and ICAM-1 Expression by Cytokines and Retinoids in HPV-Harboring Keratinocyte Lines

      • Slawomir Majewski, Francoise Breitburd, Gerard Orth, Stefania Jablonska
      Pages 207-211

    8. Murine Cytotoxic T Cell Responses to Human Papillomavirus E7 Protein

      • Elena Sadovnikova, Xiaojiu Zhu, Shona M. Collins, Peter Beverley, Hans J. Stauss
      Pages 213-218

    9. Immune Response to Human Papillomavirus Type 16 E6 Oncoprotein

      • L. Gao, B. Chain, C. Sinclair, L. Crawford, J. Zhou, J. Morris et al.
      Pages 219-226

    10. Human Cytotoxic T Cell Epitopes in HPV 11: Relationships between Allele-Specific Motifs, HLA Binding, and Stimulation in Vitro

      • Huw Davies, Ian Tarpey, Simon Stacey, Julian Hickling, Jennifer Bartholomew, Humphrey Birley et al.
      Pages 227-232

    11. An Immunodominant Region in HPV16.L1 Identified by T Cell Responses in Patients with Cervical Dysplasias

      • Philip S. Shepherd, Andrea J. Rowe, Jeremy C. Cridland, Michael G. Chapman, Jenny C. Luxton, Lee S. Rayfield
      Pages 233-241

    12. Immunological Aspects of Cervical Carcinoma

      • Carina G. J. M. Hilders, Jaap D. H. van Eendenburg, Yvonne Nooyen, Gert Jan Fleuren
      Pages 243-248

    13. Analysis of Tumour-Infiltrating Lymphocytes in Cervical Carcinoma

      • Anna K. Ghosh, Suzanne Glenville, Jenny Bartholomew, Peter L. Stern
      Pages 249-253
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About this book

This volume represents a series of papers presented at the Second International Workshop on HPV Immunology held at the University of Cambridge July 5-7 1993. This Workshop and its predecessor held in Amsterdam in May 1992 were two of the major activities of the European Concerted Action "Immunology of Human Papillomavirus and Vaccine Development". The Concerted Action (CA) was supported by grants from the Commission of the European Communities (EC), the French Association for Cancer Research (ARC) and the European Association for Medical Research (EAMR). Twenty­ two laboratories throughout Europe and Scandinavia were members of the CA, the objectives of which were to develop collaborations, implement scientific exchanges and co-operate in a collective effort to develop vaccination strategies for HPV. HPV's are ubiquitous pathogens and evidence which has been accumulated over the past decade leaves little doubt that infection with certain HPV types (the so called "oncogenic HPV's" 16, 18 and their relatives) is the major risk factor in the development of cancer of the uterine cervix in women. Since an infectious agent, a virus, is implicated as the main aetiologic factor in this disease, the possibility is raised that if one could prevent HPV infection or treat established infections this would be an effective anti-cancer strategy against what is the commonest cancer in women worldwide.

Editors and Affiliations

  • Department of Pathology, University of Cambridge, Cambridge, UK

    Margaret A. Stanley

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