Steroid Contraceptives and Women’s Response

Regional Variability in Side-Effects and Pharmacokinetics

  • Rachel Snow
  • Peter Hall

Part of the Reproductive Biology book series (RBIO)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Rachel C. Snow, Lucy E. Wilson
    Pages 1-7
  3. Harold A. Nash, Dale N. Robertson
    Pages 91-102
  4. D. J. Back, M. L’E. Orme
    Pages 103-123
  5. Christopher Longcope
    Pages 143-151
  6. Leon Bradlow
    Pages 171-177

About this book

Introduction

Pharmacokinetic variability of contraceptive steroids is a relatively under-explored area of contraceptive research, and hardly a common point of discussion among those who plan and deliver family planning services. Nevertheless, numerous independent studies over the last 15 years have indicated that women in different regions of the world vary in their pharmacokinetic response to contraceptive steroids. The causes of such variability are not known, but it has important consequences for contraceptive effectiveness. It may also offer insight to the basis of contraceptive side-effects. The impetus for this volume was to collect documentation of pharmacokinetic variability of contraceptive steroids, and to explore both the possible causes and implications of these data. Factors known to affect steroid pharmacokinetics, such as concurrent use of specific medications, are reviewed by Back and Orme. Other factors known to affect endogenous steroid dynamics are presented in chapters by Bradlow, Longcope, Goldin and Snow, because of their possible role in contraceptive steroid pharmacokinetics.

Keywords

kinetics metabolism pharmacokinetics pharmacology research steroids

Editors and affiliations

  • Rachel Snow
    • 1
  • Peter Hall
    • 2
  1. 1.Department of Population and International HealthHarvard School of Public HealthBostonUSA
  2. 2.World Health OrganizationGeneva 27Switzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-2445-8
  • Copyright Information Springer-Verlag US 1994
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-306-44718-1
  • Online ISBN 978-1-4615-2445-8
  • About this book